Publications by authors named "Sam Schmidt"
Methods Mol Biol
July 2023
Article Synopsis
- - The text discusses how single-cell RNA sequencing (scRNA-seq) can be used to profile immune cells, particularly focusing on designing monoclonal antibodies (mAbs).
- - It describes a process where scRNA-seq helps identify B-cell receptor sequences from immunized mice as a foundation for developing single-chain antibody fragments (scFabs) on yeast for efficient testing.
- - The method mentioned allows for integration with various in silico tools to enhance antibody properties like affinity, stability, solubility, and immunogenicity, although detailed explanations are not fully covered.
