Publications by authors named "Sam S Linton"
Article Synopsis
- Ceramide 1-phosphate (C-1-P) is a bioactive sphingolipid that directs the migration of certain cells, particularly in the immune system, but its interacting proteins were previously unknown.
- The study identifies that C-1-P interacts with a protein complex made of annexin a2 and p11, which facilitates cellular invasion through barriers, specifically in endothelial cells.
- Experimental techniques show that this interaction is crucial for C-1-P's chemotactic effects, as knocking down either annexin a2 or p11 significantly reduces C-1-P's ability to promote cell movement.
