Cellular RNA interacts with MAVS to promote antiviral signaling.

Antiviral signaling downstream of RIG-I-like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that provide allosteric regulation or act as molecular guides or scaffolds. We hypothesized that RNA plays a role in organizing MAVS signaling platforms.

CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.

Immune signaling needs to be well-regulated to promote clearance of pathogens, while preventing aberrant inflammation. Interferons (IFNs) and antiviral genes are activated by the detection of viral RNA by RIG-I-like receptors (RLRs). Signal transduction downstream of RLRs proceeds through a multi-protein complex organized around the central adaptor protein MAVS.

Encapsulation of Fragrances in Micro- and Nano-Capsules, Polymeric Micelles, and Polymersomes.

Fragrances are ubiquitously and extensively used in everyday life and several industrial applications, including perfumes, textiles, laundry formulations, hygiene household products, and food products. However, the intrinsic volatility of these small organic molecules leaves them particularly susceptible to fast depletion from a product or from the surface they have been applied to. Encapsulation is a very effective method to limit the loss of fragrance during their use and to sustain their release.

Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators.

We report a significant decrease in transcription of the G protein-coupled receptor GPR39 in striatal neurons of Parkinson's disease patients compared to healthy controls, suggesting that a positive modulator of GPR39 may beneficially impact neuroprotection. To test this notion, we developed various structurally diverse tool molecules. While we elaborated on previously reported starting points, we also performed an in silico screen which led to completely novel pharmacophores.

High SARS-CoV-2 Attack Rate Following Exposure at a Choir Practice - Skagit County, Washington, March 2020.

On March 17, 2020, a member of a Skagit County, Washington, choir informed Skagit County Public Health (SCPH) that several members of the 122-member choir had become ill. Three persons, two from Skagit County and one from another area, had test results positive for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Another 25 persons had compatible symptoms.

The Development of a Methodology for Contextual User Research in Healthcare Design Projects.

The impact of human factors in the usage of medical devices and delivery of healthcare is increasingly being recognized as a significant contributor to patient experience and safety. This paper presents a methodology for undertaking contextual user research during healthcare design projects (in home, primary or acute care settings) by which all relevant human factors of a procedure can be recorded, documented and analyzed. An innovative method of graphically representing the results of this analysis is proposed which visualizes the interactions and interdependencies between all stakeholders and artefacts involved in a procedure and the environment in which it takes place.

Psychologically informed practice (PIP) for staff working with offenders with personality disorder: A pragmatic exploratory trial in approved premises.

Background: Rates of reoffending and recall are high among released male prisoners with personality disorder. There is a need for innovative intervention to reduce offending and increase staff confidence in working with such men.

Aim: The aim of this study was to evaluate the effectiveness of a novel intervention consisting of training and consultation termed 'psychologically informed practice', within community-based 'approved premises' for offenders.