Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers.

This cohort study assesses characteristics and outcomes among adults hospitalized with coronavirus disease 2019 (COVID-19) at US medical centers as well as COVID-19–related mortality over the initial 6 months of the pandemic.

A Rapid Decrease in Stroke, Acute Coronary Syndrome, and Corresponding Interventions at 65 United States Hospitals Following Emergence of COVID-19.

Background Following the emergence of coronavirus disease 2019 (COVID-19), early reports suggested a decrease in stroke and acute coronary syndrome (ACS). We sought to provide descriptive statistics for stroke and ACS from a sample of hospitals throughout the United States, comparing data from March 2020 to similar months pre-COVID. Methods We performed a retrospective analysis of 65 academic and community hospitals in the Vizient Clinical Data Base.

Decreasing Incidence of Skin and Soft-tissue Infections in 86 US Emergency Departments, 2009-2014.

Background: The incidence of skin and soft-tissue infections (SSTIs), for which human immunodeficiency virus (HIV) is a significant risk factor, in United States emergency departments (EDs) increased dramatically after 2000 with the emergence of community-associated methicillin-resistant Staphylococcus aureus. Few studies have examined SSTI incidence among HIV-infected and non-HIV-infected patients in the United States after 2010.

Methods: Data were obtained for patient encounters at all academic medical center EDs affiliated with the Vizient clinical data warehouse assigned an SSTI-associated code based on the International Classification of Diseases, Ninth Revision, between 1 January 2009 and 31 December 2014.

Variation by center and economic burden of readmissions after liver transplantation.

The rate and causes of hospital readmissions after liver transplantation (LT) remain largely unknown in the United States. Adult patients (n = 11,937; 43.1% of all LT cases) undergoing LT from 2007 to 2011 were examined with a linkage of the University HealthSystem Consortium and Scientific Registry of Transplant Recipients databases to determine the incidence and risk factors for 30-day readmissions and utilization metrics 90 days after LT.

Effect of pretransplant diabetes on short-term outcomes after liver transplantation: a national cohort study.

Background & Aims: We sought to analyse the effect of pretransplant diabetes on post-operative outcomes and resource utilization following liver transplantation.

Methods: A retrospective cohort study was designed using a linkage between the University HealthSystem Consortium and Scientific Registry of Transplant Recipients databases. We identified 12 442 patients who underwent liver transplantation at 63 centres from 2007-2011 and separated cohorts of patients with diabetes (n = 2971; 24%) and without (n = 9471; 76%) at the time of transplant.

The status of adult inpatient care by family physicians at US academic medical centers and affiliated teaching hospitals 2003 to 2012: the impact of the hospitalist movement.

Background And Objectives: Over the past 10--15 years, the number of hospitalists has grown from a few hundred to over 30,000, and hospitalists have assumed a greater proportion of the care of hospitalized patients. No existing studies report on the impact this movement has had on the characteristics of the hospital practice of family physicians in teaching hospitals. To explore this impact we examined the volume and scope of discharges by family physicians at teaching hospitals in 2003 and 2012, the most recent decade of hospitalist growth.

Costs of outpatient thyroid surgery from the University HealthSystem Consortium (UHC) database.

Objective: To compare the cost of same-day vs 23-hour observation outpatient thyroidectomy at US academic medical centers.

Study Design: Cross-sectional analysis of a national database.

Setting: The University HealthSystem Consortium (UHC) data collected from discharge summaries.

The Analytic Information Warehouse (AIW): a platform for analytics using electronic health record data.

Objective: To create an analytics platform for specifying and detecting clinical phenotypes and other derived variables in electronic health record (EHR) data for quality improvement investigations.

Materials And Methods: We have developed an architecture for an Analytic Information Warehouse (AIW). It supports transforming data represented in different physical schemas into a common data model, specifying derived variables in terms of the common model to enable their reuse, computing derived variables while enforcing invariants and ensuring correctness and consistency of data transformations, long-term curation of derived data, and export of derived data into standard analysis tools.

Aspirin and clopidogrel use in the early postoperative period following on-pump and off-pump coronary artery bypass grafting.

Objective: Preoperative use of clopidogrel increases the risk of bleeding, but its postoperative use has not been studied. We studied early postoperative clopidogrel use in on-pump and off-pump coronary artery bypass grafting.

Methods: Data were obtained from the University HealthSystem Consortium database.

Safety of selective serotonin reuptake inhibitor in adults undergoing coronary artery bypass grafting.

Selective serotonin reuptake inhibitors (SSRIs) are commonly used in patients with coronary artery disease and depression, but they have been reported to increase the risk for bleeding. However, data on the short-term outcomes comparing SSRI and non-SSRI antidepressant use after coronary artery bypass grafting (CABG) are limited. A retrospective analysis was conducted of 1,380 adults who received any antidepressants before CABG from 2003 to 2006 at academic medical centers participating in the University HealthSystem Consortium.

Racial disparity in the relationship between hospital volume and mortality among patients undergoing coronary artery bypass grafting.

Objective: To examine whether the volume-mortality relationship in coronary artery bypass grafting (CABG) differs by race and operative risk.

Summary Background Data: In-hospital mortality after CABG is inversely associated with hospital volume. Racial disparities exist in the outcomes of CABG, possibly due to blacks' high operative risk.

Venous thromboembolism in elective operations: balancing the choices.

Background: Venous thromboembolism (VTE) is a recognized cause of morbidity and mortality in hospitalized patients and is reported to account for 250,000 deaths annually. Recent shifts in prophylaxis administration are occurring among surgical specialty groups after observing a lower rate of VTE among patients undergoing elective operation. We report the incidence of VTE from 3 sources to provide an estimate of the true risk of the complication in elective surgery.