Publications by authors named "Sam E J Paton"
Article Synopsis
- Major depressive disorder (MDD) affects a significant portion of the population and many do not respond to typical antidepressants, suggesting biological factors at play, particularly involving the gut-brain connection.
- Chronic stress negatively impacts the intestinal barrier in mice, affecting gene expression related to tight junctions and altering gut microbiota, with variations observed between sexes.
- This study highlights how stress influences gut health, potentially linking disruptions in the intestinal barrier to depression mechanisms, and shows parallels in blood samples from women diagnosed with MDD.
Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences.
View Article and Find Full Text PDF