Immersive virtual reality as a novel approach to investigate the association between adverse events and adolescent paranoid ideation.

Purpose: Paranoid ideation is common among adolescents, yet little is known about the precursors. Using a novel immersive virtual reality (VR) paradigm, we tested whether experiences of bullying, and other interpersonal/threatening events, are associated with paranoid ideation to a greater degree than other types of (i) non-interpersonal events or (ii) adverse childhood experiences.

Methods: Self-reported exposure to adverse life events and bullying was collected on 481 adolescents, aged 11-15.

Measuring coefficient of thermal expansion of materials of micrometre size using SEM/FIB microscope with in situ MEMS heating stage.

A new method is proposed to measure the linear coefficient of thermal expansion (CTE) of solid metals and ceramics of micron-sized dimensions. This approach uses a focused ion beam (FIB) to extract and transfer a slab of the sample, typically (15-20) ×10 × (3-5) µm onto a Micro-Electro-Mechanical Systems (MEMS) in situ heating holder inside a scanning electron microscope (SEM). CTE is thereafter calculated by image correlating the change of length (ΔL) between the fiducial marks on the slab as a function of temperature, taking advantage of the temperature calibration of the MEMS heating holder and nanometre resolution of the scanning electron microscope.

Breakdown and Modification of Microplastic Beads by Aeolian Abrasion.

Saltation is an important wind erosion process that can cause the modification and breakdown of particles by aeolian abrasion. It is recognized that microplastic particles can be transported by wind, but the effect of saltation on microplastic properties is unknown. This study examined the impact of simulated saltation alongside quartz grains on the size, shape, and surface properties of spherical microplastic beads.

External Validation of Clinical Prediction Models in Unilateral Primary Aldosteronism.

Background: Targeted treatment of primary aldosteronism (PA) is informed by adrenal vein sampling (AVS), which remains limited to specialized centers. Clinical prediction models have been developed to help select patients who would most likely benefit from AVS. Our aim was to assess the performance of these models for PA subtyping.

Prevalence of conduct problems and social risk factors in ethnically diverse inner-city schools.

Background: In the UK, around 5% of 11-16-year olds experience conduct problems of clinical importance. However, there are limited data on prevalence of conduct problems by ethnic group, and how putative social risk factors may explain any variations in prevalence. This study has two main aims: (1) to estimate the prevalence and nature of conduct problems overall, and by ethnic group and gender, among adolescents in diverse inner-city London schools; (2) to assess the extent to which putative risk factors - racial discrimination, socioeconomic status, parental control, and troublesome friends - explain any observed differences in prevalence of conduct problems between ethnic groups.

Repeat Adrenal Vein Sampling in Aldosteronism: Reproducibility and Interpretation of Persistently Discordant Results.

Context: The reproducibility of adrenal vein sampling (AVS) is unknown.

Objective: This work aimed to determine reproducibility of biochemical results and diagnostic lateralization in patients undergoing repeat AVS.

Methods: A retrospective chart review was conducted of single-center, single-operator AVS procedures at a tertiary care center.

Surgical Outcomes Among Primary Aldosteronism Patients Without Visible Adrenal Lesions.

Context: Many patients with unilateral primary aldosteronism (PA) have normal adrenal imaging, but little is known about their outcome following adrenalectomy.

Objective: To evaluate biochemical and clinical outcomes after adrenalectomy in patients with unilateral PA and normal-appearing adrenal imaging.

Design: Retrospective cohort study of patients seen between January 2006 and May 2018.

Unilateral Disease Is Common in Patients With Primary Aldosteronism Without Adrenal Nodules.

Background: Patients with primary aldosteronism (PA) without apparent adrenal nodularity have not been well characterised in the literature. The aim of this study was to assess for unilateral aldosterone hypersecretion among patients with primary aldosteronism with normal-appearing adrenals using adrenal vein sampling (AVS).

Methods: In this cross-sectional study performed at a Canadian tertiary care centre, we reviewed all consecutive PA patients lacking a definitive adrenal nodule who were referred for AVS in the work-up of PA between January 2006 and May 2018.

Development of a cost model for the production of carbon fibres.

Carbon fibre composites offer considerable potential for mass reduction in automotive applications. However, raw material cost is one of the major factors that constraints its extensive use in this mass market. Here we report a systematic study that presents the cost contributors by considering the entire process chain of the carbon fibre manufacturing.

Testing the ability of the nonalcoholic fatty liver disease fibrosis score to predict 1-year all-cause hospital admission.

The nonalcoholic fatty liver disease fibrosis score (NFS) has been shown to be a cost-effective screening strategy in the primary care setting to determine when gastroenterology referral is needed, but NFS as a predictor of hospitalization within 1 year is uncertain. This retrospective observational cohort study involved 1803 patients with a diagnosis of nonalcoholic fatty liver disease or nonalcoholic steatohepatitis. The NFS was categorized into the following: low (less than -1.

Discordance Between Imaging and Adrenal Vein Sampling in Primary Aldosteronism Irrespective of Interpretation Criteria.

Background: Subtyping of primary aldosteronism (PA) using imaging and adrenal vein sampling (AVS) may yield discordant results, causing confusion in management. Interpretation criteria for AVS lateralization may affect discordance rates.

Methods: We identified consecutive patients with PA who underwent AVS at a quaternary care center between January 2006 and May 2018.

Generalizability of clinical trials of advanced melanoma in the real-world, population-based setting.

Results from novel therapeutics trials are not always generalizable to real-world patients. We aimed to determine the pattern in which trial findings are applied in a population-based setting of melanoma patients and consequent treatment outcomes. Patients with unresectable disease during 2011-2014 and referred to cancer centers in a large Canadian province were retrospectively reviewed.

Influence of rurality on diagnosing dementia in Australian general practice.

This article reviews the literature concerning barriers in making a diagnosis of dementia in general practice and examines these from a rural perspective. It is proposed that the increasing prevalence of dementia in coming years in Australia will be felt most keenly in rural communities where there are already shortages of GPs and dementia-specific services to manage growing demand. Evidence suggests that dementia is often not specifically diagnosed by GPs and that this is a global issue.

VEGF-Trap: a VEGF blocker with potent antitumor effects.

Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. Initial attempts to block VEGF by using a humanized monoclonal antibody are beginning to show promise in human cancer patients, underscoring the importance of optimizing VEGF blockade. Previous studies have found that one of the most effective ways to block the VEGF-signaling pathway is to prevent VEGF from binding to its normal receptors by administering decoy-soluble receptors.

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Mammalian cells constantly monitor and respond to a myriad of extracellular signals, often by using cell surface receptors. Two important classes of cell surface receptors include the receptor tyrosine kinases, which recognize peptide growth factors such as insulin, and the integrins, which most often mediate binding to components of the extracellular matrix. We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases.