Publications by authors named "Sam Augustine Kandathil"
Cancer-associated cachexia in head and neck squamous cell carcinoma (HNSCC) is challenging to diagnose due to its complex pathophysiology. This study aimed to identify metabolic biomarkers linked to cachexia and survival in HNSCC patients using [F]FDG-PET/CT imaging and machine learning (ML) techniques. We retrospectively analyzed 253 HNSCC patients from Vienna General Hospital and the MD Anderson Cancer Center.
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- Sinonasal malignancies that invade the orbit have poor prognoses, but a new surgical approach called extended-orbital exenteration (EOE) shows promise in improving outcomes.
- * A study conducted across three institutions involved 48 orbital dissections and utilized a questionnaire to assess the procedure's feasibility and safety, with feedback from 25 surgeons.
- * The findings indicate that while endoscopic-EOE is challenging, it is a feasible procedure that needs further clinical validation to evaluate its effectiveness in real-life situations.
Background: Flaps have become an integral part of plastic and reconstructive surgery. The robust blood supply of such flaps is a prerequisite to reduce flap failure. Despite the reported versatility of the occipital flap, comprehensive anatomical studies on its perforators and perforasomes are lacking.
View Article and Find Full Text PDFBackground: Young patients with tongue squamous cell carcinoma (TSCC) mostly lack typical prognostic markers and face a dire prognosis. The aim of this study was to analyze the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in TSCC patients, with a special emphasis on patients under 45 years.
Methods: This retrospective study included all patients primarily treated for TSCC.
Purpose: Human papilloma virus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) displays distinct epidemiological, clinical, and molecular characteristics compared to the negative counterpart. Alterations in autophagy play an important role in cancer, and emerging evidence indicates an interplay of autophagy in HNSCC carcinogenesis and tumor promotion. However, the influence of HPV infection on autophagy in HNSCC has received less attention and has not been previously reviewed.
View Article and Find Full Text PDFBackground: The peroneus tertius muscle (PT) is one of the extensor muscles of the lower leg, often described as a variable separation from the extensor digitorum longus muscle (EDL). According to literature it has six different types of insertion, one of them (Olewnik Type IV) having two tendons inserting to the fifth metatarsal bone (FMTB). Morphometric data about this type of insertion is sparse, especially the relation between the two tendons, albeit the PT is suspected to contribute to stress fractures of the FMTB.
View Article and Find Full Text PDFBackground: New chemotherapy agents are warranted for head and neck squamous cell carcinoma (HNSCC), particularly for incidence-rising HPV-positive tumors. Based on the evidence of Notch pathway involvement in cancer promotion and progression, we aimed to gain insights into the in vitro antineoplastic effects of gamma-secretase inhibition in HPV-positive and -negative HNSCC models.
Methods: All in vitro experiments were conducted in two HPV-negative (Cal27 and FaDu) and one HPV-associated HNSCC cell line (SCC154).