Publications by authors named "Salvina Laura Tammaccaro"
Article Synopsis
- * The study reveals that HNF1β remains attached to chromatin during both interphase and mitosis in a specific manner, aided by a protein called BTBD2 that activates Topoisomerase 1 (TOP1) during mitosis.
- * A mutation associated with "maturity onset diabetes of the young" can disrupt the interaction between HNF1β and TOP1, highlighting HNF1β's key role in chromatin remodeling and gene reactivation, which is essential for maintaining cellular identity after cell division.
KRAS is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it is a marker of poor prognosis. The first FDA-approved KRAS inhibitors, sotorasib and adagrasib, have been an enormous breakthrough for patients with KRAS mutant NSCLC; however, resistance to therapy is emerging. The transcriptional coactivators YAP1/TAZ and the family of transcription factors TEAD1-4 are the downstream effectors of the Hippo pathway and regulate essential cellular processes such as cell proliferation and cell survival.
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