Publications by authors named "Salvatore Caruccio"
Background: Osteoarthritis (OA) is a degenerative musculoskeletal disease that significantly impacts the quality of life. Currently, no validated biomarkers for early detection of OA are defined. The possibility of discovering OA biomarkers is the focus of this study.
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- * This study examines how IL-1β and TNFα influence the progression of OS through different epigenetic mechanisms, particularly focusing on TET-1 inhibition and its effects on DNA methylation of the IL-6 promoter.
- * The findings suggest that while TET-1 inhibition can completely stop tumor growth caused by IL-1β, its impact on TNFα is only partial, indicating that understanding these pathways could lead to more targeted therapies for OS.