- Sclerosing bone dysplasias are a group of disorders where osteoclasts fail to break down bone, causing dangerously high levels of bone mineral density (BMD).
- Researchers treated three children with high BMD using acetazolamide to create metabolic acidosis, aiming to boost bone resorption and lower BMD.
- All three patients responded well to the treatment, tolerating it without issues and showing satisfactory clinical improvement.