Publications by authors named "Salvador Garcia Carmona"
Article Synopsis
- The study investigates the relationship between certain genetic variants (rs2071288, rs3134940, rs184003, and rs2070600) and soluble-RAGE levels in patients with chronic obstructive pulmonary disease (COPD) related to biomass-burning smoke (BBS) and tobacco smoking.
- Researchers analyzed 2189 subjects divided into four groups to determine if these variants and RAGE levels were linked to COPD, but found no strong associations, except a marginal one for rs3134940 with COPD-BBS.
- The findings revealed that sRAGE plasma and sputum levels were lower in COPD patients compared to non-COPD individuals, with rs3134940 influencing these levels, but the genetic variants themselves did
Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema () and pulmonary fibrosis () are associated with severe COVID-19, and whether plasma mucin 5B differs according to patients' outcomes.
Materials And Methods: We included 1258 Mexican subjects diagnosed with COVID-19.
Cigarette smoking is influenced by nicotine's effects on dopaminergic activity, which appear to be moderated by genetic variation, particularly a variable number tandem repeat (VNTR, 48 bp) polymorphism in the third exon of the dopamine receptor gene (). Smokers with the VNTR ≥7 repeats (long, L allele) report markedly increased participation in some smoking behaviors; hence, our aim was to evaluate the association of the L allele in Mexican Mestizo smokers with and without COPD. The VNTR 48 bp was genotyped in 492 Mexican Mestizo smokers: 164 COPD patients (≥20 cigarettes per day, cpd), 164 heavy smokers without COPD (HS, ≥20 cpd) and 164 light smokers without COPD (LS, 1-10 cpd).
View Article and Find Full Text PDFObjectives: Tobacco smoking is a complex and multifactorial disease involving both environmental and genetic factors. In the Mexican mestizo population, single-nucleotide polymorphisms (SNPs) associated with cigarette smoking and a greater degree of nicotine addiction have been identified; however, no possible roles have been explored in regard to the age of onset of smoking or in the success of quitting.
Methods: In this study, 151 Mexican mestizo, who smoke cigarettes, were included.
Background: Genes encoding the receptors involved in the dopaminergic and serotonergic pathways are potential candidates in the mechanisms of nicotine addiction.
Aims: To identify genetic variants in the promoter regions and exons of the DRD4 and HTR2A genes associated with tobacco smoking and the degree of nicotine addiction in Mexican mestizos.
Methods: The study included 438 non-smokers (NS) and 1,157 current smokers, ranked based on their consumption of cigarettes per day (cpd): 574 heavy smokers (HS, >20 cpd) and 583 light smokers (LS, 1-10 cpd).