Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis.

Aim: Production of Matryoshka-type gastroresistant microparticles containing antibiotic-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NP) against Mycobacterium tuberculosis.

Materials & Methods: The emulsification and evaporation methods were followed for the synthesis of PLGA-NPs and methacrylic acid-ethyl acrylate-based coatings to protect rifampicin from degradation under simulated gastric conditions.

Results & Conclusion: The inner antibiotic-loaded NPs here reported can be released under simulated intestinal conditions whereas their coating protects them from degradation under simulated gastric conditions.

Photosensitized oxidation of 9,10-dimethylanthracene with singlet oxygen by using a safranin O/silica composite under visible light.

The photosensitized oxidation of 9,10-dimethylanthracene with singlet oxygen in acetonitrile was investigated using a safranin O/silica composite as an heterogeneous delivery system of the photosensitizer. The only detected product was the corresponding endoperoxide (9,10-endoperoxianthracene) and its formation rate depended on the initial concentration of DMA, the light intensity and the amount of the composite. The kinetics of this reaction was compared with that of the reported kinetic model of photosensitized oxidations of organic compounds in homogeneous reactions.