Publications by authors named "Saludar N"
Article Synopsis
- This study aimed to determine if cytokine profiles from whole-blood stimulation can effectively distinguish between latent tuberculosis infection (LTBI) and active pulmonary tuberculosis (PTB).
- The research involved 78 participants in the Philippines, examining various MTB antigens and measuring cytokine levels, revealing significant differences across the groups.
- Results suggest that specific combinations of cytokines could help differentiate between LTBI and active PTB, marking a potential advancement in tuberculosis diagnostics.
Article Synopsis
- - Diabetes and undernutrition are significant risk factors for tuberculosis (TB), with 58% of participants in a study having at least one comorbidity, including diabetes (22.5%), undernutrition (23.4%), hypertension (19.0%), and anaemia (13.5%).
- - The study involved 900 participants starting anti-TB treatment, where 54.8% of those with diabetes and 54.9% with hypertension had previously undiagnosed conditions, and poorly controlled diabetes was common among those already on medication.
- - MDR-TB treatment increased the odds of diabetes but decreased the odds of hypertension, indicating the need for TB treatment programs to address and manage comorbid conditions that could negatively
Effects of comorbidities on quality of life in Filipino people with tuberculosis.
Int J Tuberc Lung Dis
July 2020
We investigated health-related quality of life (HrQoL) in Filipino people undergoing TB treatment, and whether HrQoL was negatively impacted by comorbidity with undernutrition, diabetes (DM) and anaemia. Adult participants were enrolled in public facilities in Metro Manila (three sites) and Negros Occidental (two sites). Multivariate linear regression was used to model the four correlated domain scores from a WHOQOL-BREF questionnaire (physical, psychological, social, environmental).
View Article and Find Full Text PDFDiabetes and undernutrition are common risk factors for TB, associated with poor treatment outcomes and exacerbated by TB. We aimed to assess non-communicable multimorbidity (co-occurrence of two or more medical conditions) in Filipino TB outpatients, focusing on malnutrition and diabetes. In a cross-sectional study, 637 adults (70% male) from clinics in urban Metro Manila (N = 338) and rural Negros Occidental (N = 299) were enrolled.
View Article and Find Full Text PDFBackground: The Philippines is ranked 3rd globally for tuberculosis incidence (554/100,000 population). The tuberculosis ward at San Lazaro Hospital, Manila receives 1,800-2,000 admissions of acutely unwell patients per year with high mortality. Objectives of this prospective cohort study were to quantify the association of under-nutrition (primary) and diabetes (secondary) with inpatient mortality occurring between 3-28 days of hospital admission in patients with suspected or previously diagnosed TB.
View Article and Find Full Text PDFBody mass index (BMI) kg/m2 is a key screening tool for under-nutrition in adults, but difficult to obtain in immobile or unwell patients, particuarly in low resource settings, due to inability to accurately measure both weight and height. Mid-upper arm circumference (MUAC) is used to assess under-nutrition in children under 5 years but no standardised cut-off values exist for adults. In a cohort of adult Filipino patients admitted to a tuberculosis ward we assessed (i) cut-offs for MUAC to predict moderate under-nutrition (BMI <17kg/m2), (ii) the performance of limb lengths to predict height and; (iii) associations of body fat percentage from skinfolds and hand grip-strength with BMI.
View Article and Find Full Text PDFObjective: To investigate the prevalence of bacterial co-infection and its effect on early mortality among hospitalised human immunodeficiency virus (HIV) negative pulmonary tuberculosis (PTB) patients in Manila, the Philippines.
Design: A prospective observational study was conducted at a national infectious disease hospital. HIV-negative PTB patients aged 13 years hospitalised from November to December 2011 and from December 2012 to May 2013 were enrolled.
Objective: To determine the mortality rate and risk factors for in-hospital death among hospitalised human immunodeficiency virus (HIV) negative tuberculosis (TB) patients in poor urban areas in the Philippines.
Design: A cross-sectional study was conducted at a national infectious disease hospital in Manila City. The target population was patients aged ≥ 13 years with all forms of HIV-negative TB admitted from October to December 2009.