Nephrotic syndrome and renal impairment associated with fenclofenac.

We report a case of nephrotic syndrome and renal impairment following treatment with fenclofenac. Biopsy showed an interstitial nephritis with minor glomerular changes. Resolution occurred on withdrawal of the drug and treatment with prednisolone.

Legg-Calvé-Perthes disease. The prognostic significance of the subchondral fracture and a two-group classification of the femoral head involvement.

From previous experimental investigations of a model of Legg-Calvé-Perthes disease in young pigs, it was speculated that the early radiographic phenomenon of the subchondral crescentic-shaped radiolucent line is a pathological fracture and, furthermore, that this fracture initiates the stage of resorption. Being painful, the fracture also heralds the clinical onset of the disease. From these laboratory investigations, plus a preliminary radiographic investigation in children, it has been observed that only that portion of the epiphysis underlying the subchondral fracture is resorbed.

Foci of chronic circumscribed osteomyelitis (Brodie's abscess) that traverse the epiphyseal plate.

We observed six children who presented with chronic circumscribed osteomyelitis involving the adjacent metaphysis and epiphysis of a long bone, communicating through and damaging the growth cartilage of the epiphyseal plate. Four of the six children were less than or equal to 10 years of age. All six patients presented with the mild symptoms and subtle clinical findings that are characteristic of "Brodie's abscess," which is usually confined to metaphyseal, or occasionally epiphyseal, bone.

Innominate osteotomy in the management of residual congenital subluxation of the hip in young adults.

The application of innominate osteotomy (IO) to persistent subluxation of the hip in adults is limited. Indeed, a relatively small percentage of such adults, particularly those in the fourth and fifth decades of life, meet the precise indications and essential prerequisites for IO. Nevertheless, in most carefully selected young adults in up to and including the fifth decade of life, IO has proved successful.

Clinical application of basic research on continuous passive motion for disorders and injuries of synovial joints: a preliminary report of a feasibility study.

Since 1970, when the concept of continuous passive motion (CPM) was originated by one of the authors (R.B.S.

The effect of the volume of effusion, joint position and continuous passive motion on intraarticular pressure in the rabbit knee.

The effect of joint position and continuous passive motion (CPM) on intraarticular pressure and joint compliance was studied in 40 knee joints of 20 rabbits. Increments of 0.5 ml normal saline were injected into the knee joint and the intraarticular pressures were recorded with the knees flexed from 40 degrees to 160 degrees and during CPM.

Heterogeneity in anticatalytic activity of antibody specific for horseradish peroxidase.

Rabbit antibodies specific for horseradish peroxidase are heterogeneous in their ability to inhibit enzyme activity. Heterogeneity was demonstrated by fractionation of the total antiperoxidase pool by differential ammonium sulfate precipitation and differential elution of antibody from enzyme affinity columns. Both fractionation methods yielded antibody subpopulations that differed in anticatalytic activity.

Irritable bowel syndrome--a safe diagnosis?

Seventy-seven of 84 surviving patients in whom the irritable bowel syndrome had been diagnosed at least six years previously were reviewed. A different diagnosis was made in only four cases. Forty-four patients remained symptomatic and 29 patients had no further bowel problems.

Inhibition of horseradish peroxidase activity by specific antibody: determinant specificity of anticatalytic antibodies.

Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes.

Calmodulin activates the isolated catalytic unit of brain adenylate cyclase.

The catalytic and guanine nucleotide regulatory (G/F) units of solubilized bovine brain adenylate cyclase were separated by gel filtration as described by Strittmatter, S., and Neer, E. J.

Royal College Lecture, prevention of arthritis through preservation of cartilage.

In the face of current enthusiasm for total replacement of joints, we must not forget that much degenerative arthritis is preventable. Three causes of iatrogenic damage to articular cartilage are pressure necrosis, obliterative degeneration and drug-induced degeneration. Our experiments with continuous passive motion have shown striking beneficial effects on the healing and regeneration of cartilage.

Fractures Involving the Distal Epiphyseal plate of the femur.

Forty-two fractures involving the distal femoral epiphyseal plate in 41 patients were reviewed. The average age at injury was 11.2 years.

The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit.

A new concept, continuous passive motion of a synovial joint in vivo, was investigated to determine its biological effect on the healing of full-thickness articular cartilage defects that penetrate the subchondral bone of knee joints of adolescent and adult rabbits. The effect of continuous passive motion was compared with the effects of immobilization and of intermittent active motion. This investigation included assessment of 480 defects in the knees of 120 adolescent rabbits and assessment of 108 defects in the knees of twenty-seven adult rabbits.