Self-Diagnosed Cases of Dissociative Identity Disorder on Social Media: Conceptualization, Assessment, and Treatment.

Recent global popularity of social media content about dissociative identity disorder (DID) has coincided with increased self-diagnosis among children and young people who have formed large online communities and presented in clinical settings seeking to affirm their self-diagnoses. We situate this phenomenon within a broader trend toward self-diagnosis due to the widespread visibility and accessibility of mental health content on social media. Social media propelled self-diagnosis raises particular questions for the study and treatment of DID due to long-standing debates over whether the condition is traumagenic, sociogenic, or iatrogenic.

A Binational Sample-Initiated Retrospective Outbreak Investigation of Listeria monocytogenes Infections in the United States and Canada Linked to Enoki Mushrooms Imported from China 2022-2023.

In 2022, the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), U.

Neural crest precursors from the skin are the primary source of directly reprogrammed neurons.

Direct reprogramming involves the conversion of differentiated cell types without returning to an earlier developmental state. Here, we explore how heterogeneity in developmental lineage and maturity of the starting cell population contributes to direct reprogramming using the conversion of murine fibroblasts into neurons. Our hypothesis is that a single lineage of cells contributes to most reprogramming and that a rare elite precursor with intrinsic bias is the source of reprogrammed neurons.

Ambulance offload performance, patient characteristics and disposition for patients offloaded to different areas of the emergency department.

Objective: Ambulance transfer of care (TOC) is a key performance indicator for New South Wales EDs, with 90% of ambulances to be offloaded within 30 min of arrival. Nepean Hospital ED has a number of strategies to improve TOC, including ambulatory areas where patients can be offloaded immediately. Offload data are supplied by ambulance and there is no study into its accuracy.

Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS.

Microglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the gene, is highly upregulated in a specific microglial response state called disease-associated microglia (DAM) in various neurodegenerative conditions. However, the role of Dectin-1 in ALS is undetermined.

"Holding the badness": Therapists' experiences of treating incestuous abuse continuing into adulthood.

Objective: This study aimed to explore the experience of therapists whose clients report incestuous abuse continuing into adulthood.

Method: Ten Australian therapist-participants were recruited through professional forums. After giving informed consent, they completed a semistructured interview.

Src dependency of the regulation of LTP by alternative splicing of exon 5.

Alternative splicing of exon 5 regulates induction of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses: LTP in mice lacking the GluN1 exon 5-encoded N1 cassette (GluN1a mice) is significantly increased compared with that in mice compulsorily expressing this exon (GluN1b mice). The mechanism underlying this difference is unknown. Here, we report that blocking the non-receptor tyrosine kinase Src prevents induction of LTP in GluN1a mice but not in GluN1b.

Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females.

Chronic pain is associated with alterations in fundamental cellular processes. Here, we investigate whether Beclin 1, a protein essential for initiating the cellular process of autophagy, is involved in pain processing and is targetable for pain relief. We find that monoallelic deletion of Becn1 increases inflammation-induced mechanical hypersensitivity in male mice.

Incestuous Abuse Continuing into Adulthood: Clinical Features and Therapists' Conceptualisations.

Prolonged incest, where children are sexually abused by familial perpetrators into adulthood, has been documented in clinical and criminological scholarship, however it is often overlooked in research, policy and practice approaches to familial sexual abuse. This article draws on interviews with ten Australian therapists about their clinical work with clients subject to incestuous abuse continuing into adulthood. It outlines their descriptions of these cases, the nature of the reported abuse and factors that facilitated prolonged and ongoing incest, including at the time of therapy.

Constraining global transport of perfluoroalkyl acids on sea spray aerosol using field measurements.

Perfluoroalkyl acids (PFAAs) are highly persistent anthropogenic pollutants that have been detected in the global oceans. Our previous laboratory studies demonstrated that PFAAs in seawater are remobilized to the air in sea spray aerosols (SSAs). Here, we conducted field experiments along a north-south transect of the Atlantic Ocean to study the enrichment of PFAAs in SSA.

Broad host range phages target global bacterial strains and clear infection in five-strain model systems.

Unlabelled: is a prevalent bacterial pathogen in poultry, and due to the spread of antimicrobial resistance, alternative treatments are needed to prevent and treat infection. Bacteriophages (phages), viruses that kill bacteria, offer a viable option and can be used therapeutically to treat infections. The aim of this study was to isolate phages against strains currently circulating on farms across the world and establish their virulence and development potential using host range screening, virulence assays, and larva infection studies.

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia.

The complex and heterogeneous genetic architecture of schizophrenia inspires us to look beyond individual risk genes for therapeutic strategies and target their interactive dynamics and convergence. Postsynaptic NMDA receptor (NMDAR) complexes are a site of such convergence. Src kinase is a molecular hub of NMDAR function, and its protein interaction subnetwork is enriched for risk-genes and altered protein associations in schizophrenia.

Calcium-Dependent Hyperexcitability in Human Stem Cell-Derived Rett Syndrome Neuronal Networks.

Background: Mutations in predominantly cause Rett syndrome and can be modeled in vitro using human stem cell-derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell-derived null excitatory neurons have smaller soma size and reduced synaptic connectivity but are also hyperexcitable due to higher input resistance.

The sexual politics of technology industry responses to online child sexual exploitation during COVID-19: "This pernicious elitism".

Background: Increasing rates of online child sexual exploitation further spiked during the COVID-19 pandemic at a time of disrupted child protection capacity. While the technology industry is central to coordinated efforts to prevent online abuse and remove harmful content, it is largely exempt from formal child protection obligations.

Objective: The aim of this study was to examine the response of the technology industry to online child sexual exploitation during COVID-19 from the perspective of anti-exploitation professionals.

"You Feel Like You Did Something So Wrong": Women's Experiences of a Loved One's Child Sexual Abuse Material Offending.

This article examines the experiences of female partners and relatives of child sexual abuse material offenders and the (il)legibility of their experiences within prevailing theoretical frameworks and policy responses to violence against women. Drawing on survey and interview data with clients of a specialist support agency, we situate the lack of understanding and support available to these women within the systematic depoliticization of child sexual abuse. The article traces how women developed their own social critique of child sexual exploitation as a form of gendered violence and called for a feminist reengagement with the politics of child sexual abuse.

Parental Production of Child Sexual Abuse Material: A Critical Review.

The aim of this review is to summarize the available empirical research on parental production and to explore the discursive positioning of parental perpetrators within scholarship on child sexual abuse material (CSAM). Academic databases were searched using a combination of relevant terms, and the review was expanded as new terms were identified. The review identified 66 scholarly articles, papers, or books that referred to parental production of CSAM published since 1970.

Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I.

The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as homogenous, fixed-strength units of neural communication is becoming increasingly scrutinized. Here, we used minimal stimulation of individual glutamatergic afferent axons to evoke single synapse resolution postsynaptic responses from central sensory lamina I neurons in an adult rat spinal slice preparation.

Development and Validation of Blood-Based Predictive Biomarkers for Response to PD-1/PD-L1 Checkpoint Inhibitors: Evidence of a Universal Systemic Core of 3D Immunogenetic Profiling across Multiple Oncological Indications.

Background: Unprecedented advantages in cancer treatment with immune checkpoint inhibitors (ICIs) remain limited to only a subset of patients. Systemic analyses of the regulatory 3D genome architecture linked to individual epigenetic and immunogenetic controls associated with tumour immune evasion mechanisms and immune checkpoint pathways reveal a highly prevalent molecular profile predictive of response to PD-1/PD-L1 ICIs. A clinical blood test based on a set of eight (8) 3D genomic biomarkers has been developed and validated on the basis of an observational trial to predict response to ICI therapy.

Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain.

Background And Purpose: Chronic pain is a devastating problem affecting one in five individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics have contributed to cataloguing diverse cellular pathways and transcriptomic alterations in response to peripheral nerve injury but have focused on phenomenology and classifying transcriptomic responses.

Experimental Approach: To identifying new types of pain-relieving agents, we compared transcriptional reprogramming changes in the dorsal spinal cord after peripheral nerve injury cross-sex and cross-species, and imputed commonalities, as well as differences in cellular pathways and gene regulation.