Combination of Methotrexate and Resveratrol Reduces Pro-Inflammatory Chemokines in Human THP-1 Cells.

Introduction: Methotrexate (MTX) is a widely used anti-metabolite drug in cancer therapy, but its efficacy is often hindered by reactive oxygen species (ROS)-induced cellular toxicity. Resveratrol, a natural polyphenol, possesses antioxidant and anticancer properties. Therefore, this in vitro study aimed to investigate the synergistic anti-proliferative and anti-inflammatory effects of MTX and resveratrol in human THP-1 cells.

Frequency and Association of Polymorphisms in F2, F7, and PROS1 Coagulation Genes with Disease Severity in Coronavirus Disease 2019.

Abnormal transcriptomic profiles of coagulation genes have been linked to coagulopathies in patients with coronavirus disease 2019 (COVID-19). The objective of the present study was to explore the frequency of genotypes and potential association of polymorphisms in genes encoding coagulation factors with the disease severity in COVID-19 patients.The patients were clinically categorized into four groups of COVID-19 disease severity (asymptomatic, mild, moderate, and severe).

Ralstonia mannitolilytica infection in a tertiary care center: An outbreak report.

Background: This paper describes an outbreak of Ralstonia mannitolilytica infection declared at our facility between January-2021 and January-2022.

Methods: To identify the source of the outbreak, we applied widespread epidemiological investigations and infection control measures, including device isolation, environmental sampling, and pulsed-field gel electrophoresis typing.

Results: Thirty-six cases of R mannitolilytica infection were identified, mostly adults (78%) and males (75%).