Visible light-mediated synthesis of quinazolinones and benzothiadiazine-1,1-dioxides utilizing aliphatic alcohols.

The activation and utilization of challenging aliphatic alcohols like methanol and ethanol is a very appealing approach to synthesize valuable organic molecules. Utilization of methanol and ethanol as a coupling partner has emerged as a valuable alternative to synthesize industrially relevant -heterocycles because they can be easily procured from renewable sources unlike other activated coupling partners which are expensive and also unstable. Herein, a mild and metal-free photocatalytic protocol to synthesize quinazolinones and more challenging benzothiadiazine-1,1-dioxides, which is unprecedented at room temperature, is demonstrated.

Metal-Free Visible-Light Induced Oxidative Cleavage of C(sp )-C, and C(sp )-N Bonds of Nitriles, Alcohols, and Amines.

Selective cleavage of unstrained (sp ) C-C/ C-N bonds under mild conditions is highly challenging due to the higher bond dissociation energy. A visible light mediated metal-free oxidative dehomologation of aryl acetonitriles, primary alcohols and diols to carboxylic acids via organophotocatalyzed C(sp )-CN, C(sp )-C(OH) bond cleavage is reported. Notably, this methodology was further extended towards selective synthesis of aldehydes via deamination of both primary as well as secondary amines.

Activation of Ethanol via Conjunction of a Photocatalyst and a HAT Reagent for the Synthesis of Benzimidazoles.

The transformation of ethanol to value-added chemicals has tremendous potential. However, generally, harsh reaction conditions are needed for the functionalization of ethanol due to its high dehydrogenation energy. Herein, a metal-free photo-mediated activation of challenging ethanol and higher aliphatic alcohols for the synthesis of differently functionalized benzimidazoles under mild conditions is disclosed.

Tandem synthesis of -methylated tertiary amines three-component coupling of carbonyl compounds, amines, and methanol.

An Ir-catalyzed tandem synthesis of various -methylated tertiary amines from three-component coupling of carbonyl compounds, amines, and methanol following reductive amination/-methylation is reported for the first time. A wide array of substrates with tolerance of different functional groups was demonstrated. The protocol was extended to the synthesis of -methyl containing pharmaceutically important drug molecules.

Water as a solvent: transition metal catalyzed dehydrogenation of alcohols going green.

The long-established practice of using organic solvents in synthetic chemistry is currently becoming a major focus of environmental alarms as many of the chemical wastes are generated in the form of organic solvents. Recently, various alternative solvents have been recognized by the scientific community, including water, ionic liquids, supercritical fluids, glycerol, polyethylene glycol, . Among these alternatives, water is unquestionably an ideal solvent as it is abundant, cheap, non-toxic, and non-flammable.