Publications by authors named "Salome Masrani"
Article Synopsis
- Cherubism is linked to mutations in the SH3BP2 gene, with recent studies revealing that autoinflammation driven by TNF-α plays a significant role in the condition.
- Research on cherubism mice shows that inflammation is MYD88 dependent and that mutant macrophages have heightened reactions to pathogens and tissue damage signals, leading to excessive TNF-α production.
- The study indicates that oral bacteria and damage signals during jawbone remodeling likely lead to the specific appearance of cherubism lesions in the jaw, while reduced damage signals after jaw stabilization may explain why these lesions diminish after puberty.
