High-sensitivity cardiac troponin T and N-terminal b-type natriuretic propeptide are associated with cardiac and all-cause mortality in older adults - A population-based ten-year follow-up study.

Background: Cardiac troponin T (cTnT) and N-terminal B-type natriuretic propeptide (proBNP) are mainly used as biomarkers to diagnose specific conditions of the heart, but they also have predictive ability. Our aim was to study their associations with cardiovascular and all-cause mortality in an older population in non-acute conditions.

Methods: A population-based study with a ten-year follow-up.

AEGIS-AcutE Geriatric Intervention Study: pilot study of frontline acute geriatric assessment to improve quality of care in emergency department.

Introduction: Due to the increasing number of older patients in emergency departments (EDs) with frailty, cognitive impairment and multimorbidity, there is a need for geriatric expertise in EDs.

Methods: This retrospective study is of older patients visiting Turku University Hospital ED between 2 January and 31 December 2022. Patients aged 75 years of older were screened for frailty using Triage Risk Screening Tool (TRST) and Clinical Frailty Scale (CFS).

Comparative assessment of heel rise detection for consistent gait phase separation.

Background: Accurate identification of gait events is crucial to reliable gait analysis. Heel rise, a key event marking the transition from mid-stance to terminal stance, poses challenges in precise detection due to its gradual nature. This leads to variability in accuracy across studies utilizing diverse measuring techniques.

Predicting successful ageing among older adults seems possible even as far as two decades ahead.

Background: Successful ageing is the term often used for depicting exceptional ageing and can be measured with multidimensional models including physical, psychological and social wellbeing. The aim of this study was to test multidimensional successful ageing models to investigate whether these models can predict successful ageing, and which individual subcomponents included in the models are most significantly associated with successful ageing.

Methods: Successful ageing was defined as the ability to live at home without daily care at the age of 84 years or over.

A novel method for accurate division of the gait cycle into seven phases using shank angular velocity.

Background: Accurate detection of gait events is crucial for gait analysis, enabling the assessment of gait patterns and abnormalities. Inertial measurement unit (IMU) sensors have gained traction for event detection, mainly focusing on initial contact (IC) and toe-off (TO) events. However, effective detection of other key events such as heel rise (HR), feet adjacent (FA), and tibia vertical (TBV) is essential for comprehensive gait analysis.

New reference limits for cardiac troponin T and N-terminal b-type natriuretic propeptide in elders.

Background And Aims: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute myocardial infarctions (AMIs) was studied using these reference limits in an older population with and without previous heart diseases.

Materials And Methods: A population-based study with a ten-year follow-up.

National treatment guidelines poorly achieved among older subjects with type 2 diabetes - call to action!

Objective: To assess risk factors and factors associated with nonachievement of the treatment target levels among 75-year-old Finns with type 2 diabetes (T2D).

Design: Cross-sectional study.

Setting: Outpatient.

Gyroscope sensor data of shank motion during normal and barefoot walking.

In recent years, shank angular velocity (SAV) has emerged as a valuable tool for accurate temporal gait analysis and motion pattern assessment. To explore SAV among healthy subjects and its capability to distinguish differences between walking conditions, three-dimensional SAV data was measured with a gyroscope sensor during normal and barefoot walking. The resulting dataset contains measurement data from 58 healthy adult subjects aged 19 to 75 years.

Highly pathogenic avian influenza A(H5N1) virus infection on multiple fur farms in the South and Central Ostrobothnia regions of Finland, July 2023.

Since mid-July 2023, an outbreak caused by highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.

The association of previous night's sleep duration with cognitive function among older adults: a pooled analysis of three Finnish cohorts.

Study Objectives: Sleep duration has been shown to associate with cognitive function, but little is known about the short-term effect of sleep duration on the previous night. This study examines how usual sleep duration and previous night's sleep duration are associated with cognitive function in older adults.

Methods: The study population consisted of 2949 adults aged 59-92 years (mean 72.

Re-examination of successful agers with lower biological than chronological age still after a 20-year follow-up period.

Background: Successful ageing is the term often used for depicting exceptional ageing but a uniform definition is lacking. The aim was to re-examine and describe the successful agers living at home at the age of 84 years or over after a 20-year follow-up. The purpose was also to identify possible factors leading to their successful ageing.

Senior Health Clinic for 75-year-old home-dwelling Finns - study design, clinic protocol and non-response analysis.

Background: In the Finnish policy on older people preventive activities, which maintain functional capacity and independent living, are emphasized. The Turku Senior Health Clinic, aimed at maintaining independent coping of all home-dwelling 75-year-old citizens in the city of Turku, was founded in the beginning of 2020. The aim of this paper is to describe design and protocol of the Turku Senior Health Clinic Study (TSHeC) and provide results of the non-response analysis.

A novel easy-to-use index to predict institutionalization and death in older population - a 10-year population-based follow-up study.

Background: Various indexes have been developed to estimate the risk for mortality, institutionalization, and other adverse outcomes for older people. Most indexes are based on a large number of clinical or laboratory parameters. An index based on only a few parameters would be more practical to use in every-day clinical practice.

Ceramides and Phosphatidylcholines Associate with Cardiovascular Diseases in the Elderly.

Background: The ceramide- and phospholipid-based cardiovascular risk score (CERT2) has been found to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular mortality. In the present study, our aim was to estimate the predictive ability of CERT2 for mortality of CVD, coronary artery disease (CAD), and stroke in the elderly and to compare these results with those of conventional lipids.

Methods: We conducted a prospective study with an 18-year follow-up period that included a total of 1260 participants ages ≥64 years.

The European Union's responses to the COVID-19 crisis: How to fight a pandemic with the internal market.

In a liberalized market economy, states tend to purchase supplies required for producing publicly funded services, such as healthcare, from the markets instead of producing them themselves. The availability of critical supplies thus becomes a question of supply-side availability and supply chain management, and therefore their availability is conceptualized in terms of security of supply. The European Union's security of supply policy has focused on energy and security and defence.

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.

The midbrain reticular formation (MRF) is a mosaic of diverse GABAergic and glutamatergic neurons that have been associated with a variety of functions, including sleep regulation. However, the molecular characteristics and development of MRF neurons are poorly understood. As the transcription factor, Gata2 is required for the development of all GABAergic neurons derived from the embryonic mouse midbrain, we hypothesized that the genes expressed downstream of Gata2 could contribute to the diversification of GABAergic neuron subtypes in this brain region.

COVID-19 cases in spectators returning to Finland from UEFA Euro 2020 matches in Saint Petersburg.

UEFA Euro 2020 tournament was scheduled to take place in 2020, but due to the coronavirus disease 2019 (COVID-19) pandemic was rescheduled to start on 11 June 2021. Approximately 4500 Finnish spectators participated, travelling between Finland and Russia during the period of 16 to 30 June to attend matches played on 16 and 21 June. A total of 419 persons returning from Russia or with a connection to Russia were detected positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Increasing self-other similarity modulates ethnic bias in sensorimotor resonance to others' pain.

The tendency to simulate the pain of others within our own sensorimotor systems is a vital component of empathy. However, this sensorimotor resonance is modulated by a multitude of social factors including similarity in bodily appearance, e.g.

Orthostatic Hypotension is a Risk Factor for Falls Among Older Adults: 3-Year Follow-Up.

Objectives: To assess the prevalence of orthostatic hypotension (OH) and the association of OH with the risk of falls among community-dwelling older adults with a previous fall.

Design: Longitudinal study.

Setting And Participants: The subjects (n = 561) were participants in fall prevention conducted in western Finland.

Chronic conditions and multimorbidity associated with institutionalization among Finnish community-dwelling older people: an 18-year population-based follow-up study.

Purpose: The ageing population is increasingly multimorbid. This challenges health care and elderly services as multimorbidity is associated with institutionalization. Especially dementia increases with age and is the main risk factor for institutionalization.

GlobSnow v3.0 Northern Hemisphere snow water equivalent dataset.

We describe the Northern Hemisphere terrestrial snow water equivalent (SWE) time series covering 1979-2018, containing daily, monthly and monthly bias-corrected SWE estimates. The GlobSnow v3.0 SWE dataset combines satellite-based passive microwave radiometer data (Nimbus-7 SMMR, DMSP SSM/I and DMSP SSMIS) with ground based synoptic snow depth observations using bayesian data assimilation, incorporating the HUT Snow Emission model.

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2.

Subjective and objective health predicting mortality and institutionalization: an 18-year population-based follow-up study among community-dwelling Finnish older adults.

Background: Objective health measures, such as registered illnesses or frailty, predict mortality and institutionalization in older adults. Also, self-reported assessment of health by simple self-rated health (SRH) has been shown to predict mortality and institutionalization. The aim of this study was to assess the association of objective and subjective health with mortality and institutionalization in Finnish community-dwelling older adults.

The Association of the Brief Dementia Risk Index and Incident Dementia among Finnish 70-Year-Olds: A 5-Year Follow-Up Study.

Background: An accurate identification of older individuals at increased risk of developing dementia is very important. Various dementia risk prediction models have been developed, but not all models are applicable among older population.

Objectives: To examine the association of the Brief Dementia Risk Index (BDRI) and incidence of dementia among community-dwelling Finnish older adults.

A practical laboratory index to predict institutionalization and mortality - an 18-year population-based follow-up study.

Background: Previously, several indexes based on a large number of clinical and laboratory tests to predict mortality and frailty have been produced. However, there is still a need for an easily applicable screening tool for every-day clinical practice.

Methods: A prospective study with 10- and 18-year follow-ups.