Publications by authors named "Salman Latif Butt"
Article Synopsis
- Orf virus (ORFV) is utilized as a vector to deliver chimeric hemagglutinins (HAs) of Influenza A virus in pigs, addressing the challenge of strain-specific immunity in vaccine development.
- Researchers created two recombinant ORFVs expressing HAs that include a common stalk from a contemporary H1N1 strain along with different exotic head domains (H6 and H8).
- After vaccination, piglets showed enhanced antibody responses, indicating strong immune responses, and reduced viral shedding when challenged with divergent IAV-S strains, highlighting the potential effectiveness of ORFV-based vaccines.
Article Synopsis
- The poultry industry has used vaccinations for over 20 years to combat avian diseases, but live vaccines for Newcastle disease have notable drawbacks, such as high embryo mortality and limited early protection.
- This study tested a new recombinant live attenuated vaccine (rZJ1*L-IL4R) that includes a component aimed at enhancing immune response, administered to specific pathogen-free embryonated chicken eggs (ECEs).
- Results showed that the rZJ1*L-IL4R vaccine led to comparable hatch rates with control groups and significantly lower mortality post-vaccination, while providing strong protection against viral challenges.
Newcastle disease virus (NDV) causes a highly contagious and devastating disease in poultry. ND causes heavy economic losses to the global poultry industry by decreasing the growth rate, decrease in egg production high morbidity and mortality. Although significant advances have been made in the vaccine development, outbreaks are reported in vaccinated birds.
View Article and Find Full Text PDFRunting stunting syndrome (RSS) in commercial chickens has been reported worldwide, and although several studies have attempted to clarify the cause and describe the lesions, there are gaps in knowledge of the epidemiology, pathogenesis, and etiology. The study objective was to use commercial chicks naturally affected by RSS to describe the histologic changes of RSS in all segments of the small intestine in chicks of different ages and to identify viral gene sequences in affected chicks and their association with histologic lesions. Chicks lacking clinical signs but from the same houses and from unaffected houses were used as controls.
View Article and Find Full Text PDFNewcastle disease (ND), which is caused by Newcastle disease virus (NDV), can cause heavy economic losses to the poultry industry worldwide. It is characterised by extensive pathologies of the digestive, respiratory, and nervous systems and can cause severe damage to the reproductive system of egg-laying hens. However, it is unknown whether NDV replicates in the male reproductive system of chickens and induces any pathologies.
View Article and Find Full Text PDFArticle Synopsis
- Newcastle disease (ND), caused by the highly virulent Newcastle disease virus (NDV), poses a significant threat to global poultry production, necessitating effective tracking and management of the disease.* -
- This study demonstrates the use of next-generation sequencing (NGS) on formalin-fixed paraffin-embedded (FFPE) tissues from chickens to analyze NDV genomes, revealing two distinct lineages of a particular sub-genotype circulating in Pakistan.* -
- The findings show that using total RNA from FFPE tissues and a customized data analysis pipeline allows for improved genetic characterization of NDV, facilitating better epidemiological studies and management strategies for preventing outbreaks.*