Public Awareness of the Symptoms and Risk Factors of Thyroid Disease in Saudi Arabia.

Introduction: Thyroid disorders are a common manifestation of hormonal disorders that result from either excessive or insufficient production of thyroid hormones and the swelling of the thyroid gland. A lack of information and awareness of the signs and risk factors of thyroid problems can lead to untreated patients, thereby harming public health.

Methods: Observational cross-sectional research was conducted in the Al-Baha region of Saudi Arabia, with 531 residents selected from the general population.

Determining the Optimal Short-Term Storage Duration for T Cells Extracted from Peripheral Blood Prior Flow Cytometry Analysis.

Background: Researching medical sample storage is crucial for maintaining the integrity of biological specimens and ensuring the accuracy of research investigations and diagnostic tests. Improper storage conditions can lead to sample degradation, compromising the reliability of results. Standardized storage procedures are essential for quality control, particularly in multicenter trials where samples are collected and processed at various locations.

Functionalized iminodiacetic acid pectin/montmorillonite hydrogel for enhanced adsorption of 4-nitrophenol from simulated water: An integrated approach of response surface optimization and non-linear modeling.

This research focuses on the modification of pectin through an amination reaction, followed by the development of a novel iminodiacetic acid-functionalized pectin/montmorillonite hydrogel nanocomposite (IMAP/MMT) using gamma radiation. This composite was investigated as an adsorbent for 4-nitrophenol removal from aqueous solutions. Central composite design was utilized for numerical optimization, identifying the maximum adsorption capacity under optimal conditions [0.

Cuprospinel decorated biopolymer functionalized CNFs based electrocatalytic platform integrated with grid search optimized neural network for detection of vital amino acid in beverages.

An electrocatalytic platform based on a novel nanocomposite integrated with a grid search-optimized neural network (GSNN) was proposed for intelligent sensing of tryptophan. The cuprospinel-decorated chitosan-functionalized carbon nanofibers (CuFeO/Chit-CNFs) fabricated on a disposable electrode revealed exceptional electrocatalytic activity with a low detection limit (2 nM) and good sensitivity (79.18 μAμM cm) over a broad linear range (0.

Recent Advances in Calixarenes for the Detection of Metal Ions, Bioimaging Applications, and Anticancer Activities: A Comprehensive Review (2020-2024).

The emergence of calixarenes as versatile compounds in recent years marks a significant advancement in scientific research. In the area of analytical chemistry, calixarenes have garnered attention for their utility as selective chemosensors, enabling the sensitive and specific detection of metal ions through colorimetric and fluorimetric methods. Moreover, calixarenes have found applications in bioimaging, where they serve as effective probes for visualizing biological structures and processes with high resolution and sensitivity.

Colorimetric Detection of Cu and Ag Ions Using Multi-Responsive Schiff Base Chemosensor: A Versatile Approach for Environmental Monitoring.

In this study, we have synthesized a novel Schiff base-centered chemosensor, designated as SB, with the chemical name ((E)-1-(((6-methylbenzo[d]thiazol-2-yl) imino)methyl)naphthalen-2-ol). This chemosensor was structurally characterized by FT-IR, 1H NMR, UV-Vis and fluorescence spectroscopy. After structural characterization the chemosensor SB was subsequently employed for the detection of Cu and Ag, using fluorescence spectroscopy.

Ultrasensitive detection and photocatalytic degradation of polyketide drug tetracycline in environment and food samples using dual-functional Ag doped zinc ferrite embedded functionalized carbon nanofibers.

The efficient degradation and accurate quantification of tetracycline in environment and food samples is pivotal for ensuring public health and safety by monitoring potential contamination and maintaining regulatory standards. Hence, in this study, photocatalytic degradation of tetracycline and its electrochemical detection in environment and food samples based on dual-functional silver-doped zinc ferrite nanoparticles embedded chitosan-functionalized carbon nanofibers fabricated on a screen-printed carbon electrode (AgZFO/CHIT-CNF/SPCE) is presented. A hydrothermal method was used in the synthesis of Ag-doped ZFO, and chitosan was functionalized on the CNF surface using a swift and cost-effective chemical modification process of carboxyl groups.

Nanomolar electrochemical detection of feed additive ractopamine in meat samples using spinel zinc ferrite decorated 3-dimensional graphene nanosheets to combat food fraud in livestock industries.

Accurate detection of feed additive is significant for food safety monitoring, warding off its illegal use in livestock production, safeguarding public health, and regulatory compliance. Hence, this paper presents a cost-effective and ultrasensitive electrochemical sensor for detecting commonly used animal feed additive, ractopamine to combat food frauds in meat samples. The sensor was created by embedding spinel zinc ferrite nanospheres (ZnFeO) on three-dimensional graphene (3DG) nanosheets using sonochemical method.

Deep Learning-Based Classification of Chest Diseases Using X-rays, CT Scans, and Cough Sound Images.

Chest disease refers to a variety of lung disorders, including lung cancer (LC), COVID-19, pneumonia (PNEU), tuberculosis (TB), and numerous other respiratory disorders. The symptoms (i.e.

An ultrasensitive colorimetric and fluorescent "turn-on" chemosensor based on Schiff base for the detection of Cu in the aqueous medium.

We designed and synthesized a fluorescent "turn-on" and colorimetric chemosensor ((E)-1-((p-tolylimino)methyl)naphthalen-2-ol) SB. The structure of the synthesized chemosensor was investigated by H NMR, FT-IR, and fluorescence spectroscopy, and its sensing properties were studied toward Mn, Cu, Pb, Cd, Na, Ni, Al, K, Ag, Zn, Co, Cr, Hg, Ca, and Mg. SB showed an excellent colorimetric (yellow to yellowish brown) in MeOH and fluorescence "turn-on" sensing response to Cu in MeOH/Water (10/90, v/v) media.

Heterocyclic Organic Compounds as a Fluorescent Chemosensor for Cell Imaging Applications: A Review.

Fluorometric determination of different biologically, industrially, and environmentally important analytes is a powerful technique because this technique has excellent selectivity, high sensitivity, rapid photoluminescence response, low cost, applicability to bioimaging, and low detection limit. Fluorescence imaging is a powerful technique for screening different analytes in the living system. Heterocyclic organic compounds have been extensively used as a fluorescence chemosensor for the determination of different biologically important cations like Co, Zn, Cu, Hg, Ag, Ni, Cr, Al, Pd, Fe Pt, Mn, Sn, Pd, Au, Pd, Cd, Pb and other ions in biological and environmental systems.

Barriers and facilitators of childhood COVID-19 vaccination among parents: A systematic review.

Background: The acceptance of vaccination against COVID-19 among parents of young children plays a significant role in controlling the current pandemic. A wide range of factors that influence vaccine hesitancy in adults has been reported worldwide, but less attention has been given to COVID-19 vaccination among children. Vaccine hesitancy is considered a major challenge in achieving herd immunity, and it is more challenging among parents as they remain deeply concerned about their child's health.

The impact of altering participant MRI scanning position on back muscle volume measurements.

Objectives: Muscle volume may reflect both strength and functional capability and hence is a parameter often measured to assess the effect of various interventions. The aim of the current study was to determine the sensitivity of muscle volume calculations on participant postural position and hence gauge possible errors that may arise in longitudinal studies, especially those where an intervention leads to large muscle changes and potentially the degree of spinal curvature.

Methods: Twenty healthy participants (22-49 years, 10 male and 10 female), were recruited and MRI images acquired with them lying in four different positions; neutral spine (P1), decreased lordosis (P2), increased lordosis (P3) and neutral spine repeated (P4).

Green Synthesis and Characterization of Cobalt Oxide Nanoparticles Using Leaves Extracts and Their Photocatalytic and Biological Activities.

The advanced technology for synthesizing nanoparticles utilizes natural resources in an environmentally friendly manner. Additionally, green synthesis is preferred to chemical and physical synthesis because it takes less time and effort. The green synthesis of cobalt oxide nanoparticles has recently risen due to its physico-chemical properties.

Efficient liquid phase confiscation of nile blue using a novel hybrid nanocomposite synthesized from guar gum-polyacrylamide and erbium oxide.

In recent times, biopolymer-metal oxide nanocomposites have gained prominent importance in the attenuation of environmental toxicants from aqueous phase. But lanthanide oxide-based biopolymer nanocomposites have scantly been evaluated for their adsorption potential. A novel guar gum-polyacrylamide/erbium oxide nanocomposite (GG-PAAm/ErO NC) adsorbent was synthesized by copolymerization of guar gum (GG) and acrylamide (AAm) utilizing N-N'-methylenebisacrylamide as a crosslinker and ErO as a reinforcing agent.

Sustainable Green Synthesis of Yttrium Oxide (YO) Nanoparticles Using Leaf Extracts: Physicochemical Characterization, Photocatalytic Degradation, Antibacterial, and Anticancer Potency.

Due to their appropriate physicochemical properties, nanoparticles are used in nanomedicine to develop drug delivery systems for anticancer therapy. In biomedical applications, metal oxide nanoparticles are used as powerful and flexible multipurpose agents. This work described a green synthesis of YO nanoparticles (NPs) using the sol-gel technique with the use of aqueous leaf extracts of L (LC).

Medicinal Importance and Chemosensing Applications of Pyridine Derivatives: A Review.

Pyridine derivatives are the most common and significant heterocyclic compounds, which play an important role in various fields ranging from medicinal to chemosensing applications. Pyridine derivatives possess different biological activities such as antifungal, antibacterial, antioxidant, antiglycation, analgesic, antiparkinsonian, anticonvulsant, anti-inflammatory, ulcerogenic, antiviral, and anticancer activity. Furthermore, these derivatives have a high affinity for various ions and neutral species and can be used as a highly effective chemosensor for the determination of different species.

Statistical evaluation of liquid phase sequestration of acridine orange and Cr by novel mesoporous glutamic acid-g-polyacrylamide/plaster of paris/riboflavin hydrogel nanocomposite.

The adsorption of acridine orange and Cr ion onto plaster of paris reinforced glutamic acid-grafted-polyacrylamide hydrogel nanocomposite modified with riboflavin, Glu-g-PAM/POP/Rb HNC was studied. The Glu-g-PAM/POP/Rb HNC was physico-chemically characterized by Fourier transform infrared spectroscopy, X-ray diffraction analysis, scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, transmission electron microscopy and Brunauer-Emmett-Teller analysis. The specific surface area, pore volume and pore diameter were 15.

Formulation and Evaluation of Topical Nano-Lipid-Based Delivery of Butenafine: In Vitro Characterization and Antifungal Activity.

The present research work was designed to prepare butenafine (BN)-loaded bilosomes (BSs) by the thin-film hydration method. BN is a sparingly water-soluble drug having low permeability and bioavailability. BSs are lipid-based nanovesicles used to entrap water-insoluble drugs for enhanced permeation across the skin.

Preparation of Sodalite and Faujasite Clay Composite Membranes and Their Utilization in the Decontamination of Dye Effluents.

The present work describes the deposition of two zeolite films, sodalite and faujasite, by the hydrothermal method to tune the mesopores of clay support, which are prepared from a widely available clay depot from the central region of Morocco (Midelt). The clay supports were prepared by a powder metallurgy method from different granulometries with activated carbon as a porosity agent, using uniaxial compression followed by a sintering process. The 160 µm ≤ Φ ≤ 250 µm support showed the highest water flux compared to the supports made from smaller granulometries with a minimum water flux of 1405 L.

Synergistic Impact of Bioactive Byproduct Extract Leads to Anti- and Anti-Mycotoxin Secretion.

Fruit byproducts are considered a high source of bioactive molecules, which possess antioxidant activities. These antioxidants play principal functions in mycotoxin reduction. This study aimed to evaluate crude mandarin byproduct extract for its chemical interaction with fungal growth and suppression of mycotoxin production, and to illustrate whether the impact was regarding individual molecules or a synergistic antioxidation process.

Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin.

Polymeric nanoparticles are widely studied in the treatment of colorectal cancer. Kaempferitrin-loaded nontoxic and biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) developed by the solvent emulsion evaporation method by improving its solubility and bioavailability. In order to improve the delivery of kaempferitrin (KM) to cancerous cells, folic acid (FA) combined kaempfertrin PLGA NPs were prepared.

Electron and proton magnetic resonance spectroscopic investigation of anthracene oxidation.

The work reports a method for monitoring anthracene radical-mediated oxidation reactions using electron paramagnetic resonance (EPR) spectroscopy. The formation of anthracene dimer product was well-defined using H-NMR and H-H correlation spectroscopy (COSY). Unrestricted 3-21G/B3LYP DFT was used to estimate radical hyperfine spacing (hfs), then to identify the characteristic EPR-spin transitions of anthracene radical intermediate.