Publications by authors named "Salman Abdisalam"
Article Synopsis
- Chemotherapy is the primary treatment for triple-negative breast cancer (TNBC), and there's growing interest in targeting CD73 to enhance immunotherapy effectiveness, as it suppresses anti-cancer immunity.
- CD73 carries a dual role in promoting tumor survival by both inhibiting immune response and enabling the growth of cancer stem cells (CSCs), which may lead to tumor relapse after treatment.
- Researchers conducted in silico screening of compounds and found that quercetin and luteolin, when combined with the chemotherapy drug paclitaxel, effectively downregulated pathways associated with CD73 and CSCs, indicating a potential strategy for improved TNBC treatment outcomes.*
How effects on health equity are assessed in systematic reviews of interventions.
Cochrane Database Syst Rev
January 2022
Article Synopsis
- Systematic reviews on health equity often overlook differences in effectiveness across various equity factors, which hinders policy decisions.
- A comprehensive search was conducted in multiple databases to identify studies that examine the methods used in systematic reviews for assessing health inequalities.
- Health inequalities are defined as unfair differences in health outcomes related to social factors, and the study focused on analyzing these differences based on the PROGRESS-Plus framework, which includes various social determinants of health.