Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada).

In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik (Canada). Concentrations of metabolite were measured in plasma samples from a cross-sectional analysis of 248 children (mean age = 10.

GLUT1 expression in high-risk prostate cancer: correlation with F-FDG-PET/CT and clinical outcome.

Background: Tumour F-FDG-uptake is of prognostic value in high-risk and metastatic prostate cancer (PCa). The aim of this study is to investigate the underlying glucose metabolism mechanisms of F-FDG-uptake on PET/CT imaging in PCa.

Methods: Retrospective analysis was conducted for 94 patients diagnosed with a Gleason sum ≥8 adenocarcinoma of the prostate at biopsy between July 2011 and July 2014 who underwent F-FDG-PET/CT imaging before radical prostatectomy (RP).

Identification of Grossing Criteria for Intraoperative Evaluation by Frozen Section of Lung Cancer Resection Margins.

Because of a lack of official guidelines, systematic use of intraoperative frozen section for the evaluation of surgical margins in lung oncology constitutes standard practice in many pathology departments. This costly and time-consuming procedure seems unjustified as reported rates of positive margins remain low. We aimed to evaluate clinicopathologic criteria associated with positive margins and establish evidence-based recommendations regarding the use of frozen sections.

Overweight and obesity prevalence among Cree youth of Eeyou Istchee according to three body mass index classification systems.

Background: Little is known about the suitability of three commonly used body mass index (BMI) classification systems for Indigenous youth. We estimated overweight and obesity prevalence among Cree youth of Eeyou Istchee according to three BMI classification systems, assessed the level of agreement between them, and evaluated their accuracy through body fat and cardiometabolic risk factors.

Methods: Data on 288 youth (aged 8-17 years) were collected.

Branched-chain and aromatic amino acids in relation to behavioral problems among young Inuit from Nunavik, Canada: a cohort study.

BackgroundObesity and insulin resistance are linked with mood disorders, and elevated concentrations of branched-chain (BCAAs) and aromatic amino acids (AAAs). Our study aimed to prospectively assess the relationship between childhood plasma BCAAs and AAAs, and behavioral problems in young Inuit from Nunavik.MethodsWe analyzed data on 181 children (with a mean age of 11.

Overweight and Obesity Prevalence Among School-Aged Nunavik Inuit Children According to Three Body Mass Index Classification Systems.

Purpose: Little is known about the suitability of three commonly used body mass index (BMI) classification system for Indigenous children. This study aims to estimate overweight and obesity prevalence among school-aged Nunavik Inuit children according to International Obesity Task Force (IOTF), Centers for Disease Control and Prevention (CDC), and World Health Organization (WHO) BMI classification systems, to measure agreement between those classification systems, and to investigate whether BMI status as defined by these classification systems is associated with levels of metabolic and inflammatory biomarkers.

Methods: Data were collected on 290 school-aged children (aged 8-14 years; 50.