The expanding clinical spectrum of torpedo maculopathy.

Purpose: Torpedo maculopathy is an idiopathic, congenital, oval-shaped region of chorioretinal hypopigmentation located temporal to the macula. Torpedo lesions are typically unilateral, occasionally harbor an intraretinal cleft, and may be associated with varying degrees of hyperpigmentation. Visual acuity is usually normal, but the lesion may produce a scotoma in the visual field.

Synthesis and Characterization of a Tetramethyl Furanone Functionalized Diiminedioxime, A Potential Ligand for Cu Radiopharmaceuticals, and its Copper(II) and Nickel(II) Complexes.

As part of our on-going effort to develop (64)Cu-based radiopharmaceuticals for PET (positron emission tomography) imaging of multidrug resistance in cancer, we prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-Hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydro-furan-3-one oxime) and its Cu(II) and Ni(II) complexes. When the copper(II) complex was prepared from Cu(ClO(4))(2) in ethanol, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)(2) and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent. The Ni(II) complex is square pyramidal with the perchlorate counterion at the apex.

A lariat-functionalized copper(II) diimine-dioxime complex.

The dimeric title copper(II) complex, diaqua-1kappaO,2kappaO-bis[3,9-dimethyl-6-(2-pyridylmethyl)-4,8-diazaundeca-3,8-diene-2,10-dione dioximato(1-)]-1k(4)N(2),N(4),N(8),N(10);1:2kappa(5)O(2):N(2),N(4),N(8),N(10)-dicopper(II) diperchlorate, [Cu(2)(C(17)H(24)N(5)O(2))(2)](ClO(4))(2), crystallizes with one Cu atom in a square-pyramidal environment and the other Cu atom displaying a distorted octahedral coordination. In each case, the four N atoms in the core of the ligand (two imine and two oxime N atoms) form the base of the pyramid, with a water molecule at an apex. The two parts of the dimer are linked by an interaction [2.

Synthesis and biodistribution of a Lipophilic 64Cu-labeled monocationic Copper(II) complex.

The lipophilic, monocationic copper(II) complex of the diiminedioxime ligand 2,10-di-n-butyl-3,9-dimethyl-1,4,8,11-tetraazaundeca-1,3,8,10-tetraen-1,11-dione dioxime was synthesized and labeled with 64Cu. The biological properties of the 64Cu-labeled complex were measured in vivo and in vitro. In vivo, the complex shows uptake by the heart similar to that of 99mTc-tetrofosmin.