Publications by authors named "Salma El Bahi"
Acute myeloid leukemia, a serious condition affecting stem cells, drives uncontrollable myeloblast proliferation, leading to accumulation. Extensive research seeks rapid, effective chemotherapeutics. A potential option is a BRD4 inhibitor, known for suppressing cell proliferation.
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- BRAF inhibitors are effective against melanoma and other cancers, and this study focuses on imidazo[2,1-b]oxazole derivatives as potential mutant BRAF kinase inhibitors.
- The researchers utilized 3D-QSAR, molecular docking, and molecular dynamics simulations to evaluate these compounds, creating strong predictive models (CoMSIA/SEHA) that indicated promising anti-cancer activity and stability in the receptor's active site.
- Four inhibitors (T1-T4) were identified with favorable binding free energies and good ADMET properties, suggesting their potential for further development as anticancer medications.