Iron-Catalyzed Transfer Hydrogenation of Allylic Alcohols with Isopropanol.

Herein, we report an iron-catalyzed transfer hydrogenation of allylic alcohols. The operationally simple protocol employs a well-defined bench stable (cyclopentadienone)iron(0) carbonyl complex as a precatalyst in combination with KCO (4 mol %) and isopropanol as the hydrogen donor. A diverse range of allylic alcohols undergo transfer hydrogenation to form the corresponding alcohols in good yields (33 examples, ≤83% isolated yield).

Accessing Highly Substituted Indoles via B(CF)-Catalyzed Secondary Alkyl Group Transfer.

Herein, we report a synthetic method to access a range of highly substituted indoles via the B(CF)-catalyzed transfer of 2° alkyl groups from amines. The transition-metal-free catalytic approach has been demonstrated across a broad range of indoles and amine 2° alkyl donors, including various substituents on both reacting components, to access useful C(3)-alkylated indole products. The alkyl transfer process can be performed using Schlenk line techniques in combination with commercially available B(CF)·HO and solvents, which obviates the requirement for specialized equipment (e.

B(C F ) -Catalyzed E-Selective Isomerization of Alkenes.

Herein, we report the B(C F ) -catalyzed E-selective isomerization of alkenes. The transition-metal-free method is applicable across a diverse array of readily accessible substrates, giving access to a broad range of synthetically useful products containing versatile stereodefined internal alkenes. The reaction mechanism was investigated by using synthetic and computational methods.