Publications by authors named "Sally Zhou"
Article Synopsis
- Schlemm's canal (SC) plays a crucial role in regulating intraocular pressure, but its detailed biology is not fully understood, leading researchers to conduct extensive RNA sequencing on significant numbers of Schlemm's canal endothelial cells (SECs).
- The study identified three distinct molecular classes of SECs, differentiating between the inner and outer walls, and discovered variations in the inner wall cells that suggest their functions may be influenced by their local environment.
- Findings highlight the importance of cell junctions in fluid permeability and reveal interactions between SECs and adjacent trabecular meshwork cells, laying a new molecular groundwork for understanding glaucomatous processes and potential treatments.
Article Synopsis
- Schlemm's canal (SC) plays a crucial role in regulating intraocular pressure, but its properties and functions need further investigation, particularly the different types of endothelial cells (SECs) in its inner and outer walls.
- The study utilized bulk RNA sequencing and single-cell RNA sequencing on SECs to identify molecular characteristics, confirming a lymphatic phenotype predominate in SC and highlighting the importance of cell junctions in fluid permeability.
- The research identifies three distinct classes of SECs, reveals their interactions with trabecular meshwork cells, and lays a molecular groundwork for understanding and treating conditions like glaucoma.
Background: COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized evaluation of their accuracy and tools to aid in interpreting results are needed.
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