Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer.

Background: Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this disease every year. The five-year survival rate is 15% - significantly lower than that of other major cancers.

Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.

Background: Lung cancer is the number one cancer killer of both men and women in the United States. Three quarters of lung cancer patients are diagnosed with regionally or distantly disseminated disease; their 5-year survival is only 15%. DNA hypermethylation at promoter CpG islands shows great promise as a cancer-specific marker that would complement visual lung cancer screening tools such as spiral CT, improving early detection.

DNA methylation profile of 28 potential marker loci in malignant mesothelioma.

Patients with malignant mesothelioma (MM), an aggressive cancer associated with asbestos exposure, usually present clinically with advanced disease and this greatly reduces the likelihood of curative treatment. MM is difficult to diagnose without invasive techniques; the development of non-invasively detectable molecular markers would therefore be highly beneficial. DNA methylation changes in cancer cells provide powerful markers that are potentially detectable non-invasively in DNA shed into bodily fluids.

Fibrohistiocytic tumor of the hand after high-pressure paintgun injury: 2 case reports.

Injections from high-pressure, airless paintguns are uncommon industrial accidents that may result in acute injuries, usually to the nondominant hand. These injuries commonly require emergent management including immediate surgical debridement to avoid tissue necrosis and loss of hand function. Rarely oleogranulomas and squamous cell carcinoma have been described as late complications.