Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment.

Skeletal complications caused by osteoporosis or bone metastases are associated with considerable pain, increased mortality, and reduced quality of life. Furthermore, such events place a burden on health care resources. Agents that prevent bone resorption, such as bisphosphonates or denosumab, can reduce the risk of skeletal-related events and are widely used in patients with osteoporosis or bone metastases of cancer.

Use of unopposed systemic estrogen therapy in non-hysterectomized women: a population-based study in the UK.

A population study of 28 general practices in Oxfordshire, UK found that 0.028% of 17,712 non-hysterectomized women aged 45-60 years were using systemic unopposed estrogen. This is significantly lower than that reported in the Million Women Study.