Publications by authors named "Sally Gilbert"
Background: Atopic dermatitis (AD) is an inflammatory skin disease with significant unmet need. Blockade of the OX40-OX40 ligand (OX40L) costimulation pathway by targeting OX40L on antigen-presenting cells (APCs) with a fully human noncytotoxic, nondepleting anti-OX40L monoclonal antibody (amlitelimab; SAR445229; KY1005) is a novel way to modulate persistent inflammation.
Objectives: To assess the safety and efficacy of amlitelimab over 16 weeks in adults with AD in a phase IIa double-blind placebo-controlled study.
The safety, tolerability, immunogenicity, and pharmacokinetic (PK) profile of an anti-OX40L monoclonal antibody (KY1005, currently amlitelimab) were evaluated. Pharmacodynamic (PD) effects were explored using keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT) immunizations. Sixty-four healthy male subjects (26.
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- - Individuals who underwent gluteal-tendon repair (GTR) showed slower sit-to-stand (STS) performance compared to healthy controls, taking about 20% longer to complete the task and exhibiting a lower rate of force development.
- - Despite the differences in performance speed and force generation, there were no significant variations in joint angles or kinetics between the GTR patients and control group during the STS task.
- - The findings suggest that while GTR patients may utilize different movement strategies to perform STS, further research is needed to fully understand the implications of these variations on rehabilitation outcomes.
Aim: The aim of this study was to investigate changes in bowel function and anorectal physiology (ARP) after anterior resection for colorectal cancer.
Method: Patients were recruited from November 2006 to September 2008. Cleveland Clinic Incontinence (CCI) scores and stool frequency were determined by patient questionnaires before surgery (t ) and at three (t ), six (t ), nine (t ) and 12 (t ) months after restoration of intestinal continuity.
Article Synopsis
- Gluteal-tendon repair surgery is intended to alleviate pain and enhance mobility in patients with tendon tears, but its effects on walking patterns had not been studied before.
- The study used advanced motion analysis technology to compare walking characteristics between 25 patients who had the surgery and 29 healthy individuals matched by age and sex, focusing on various biomechanical factors like stride length and hip movement.
- Results showed that while there were no differences in some key measures like hip control, the surgery group did have shorter strides and slower walking speeds, indicating that they might still be adapting to pre-surgery gait changes; more research is needed to confirm these findings.