Fast and efficient copper-mediated F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying.

Background: Copper-mediated radiofluorination is a straightforward method to produce a variety of [F]fluoroarenes and [F]fluoroheteroarenes. To minimize the number of steps in the production of F-labelled radiopharmaceuticals, we have developed a short and efficient azeotropic drying-free F-labelling method using copper-mediated fluorination. Our goal was to improve the copper-mediated method to achieve wide substrate scope with good radiochemical yields with short synthesis time.