Hydrolyzed collagen: Exploring its applications in the food and beverage industries and assessing its impact on human health - A comprehensive review.

Hydrolyzed collagen (HC) consists of many small and low-molecular-weight amino acid chains (3-6 kDa) that can be produced either in basic or acidic media through enzymatic activity. This review details the sources of hydrolyzed collagen, its biosynthesis and its uses in the food industry, as well as its production process and beneficial health effects. HC can be extracted from a variety of sources, during which acetic acid is used for the extraction of collagen type I from bovine, porcine, marine, chicken, and fish cartilage.

Establishment of a high-content compatible platform to assess effects of monocyte-derived factors on neural stem cell proliferation and differentiation.

During neuroinflammation, monocytes that infiltrate the central nervous system (CNS) may contribute to regenerative processes depending on their activation status. However, the extent and mechanisms of monocyte-induced CNS repair in patients with neuroinflammatory diseases remain largely unknown, partly due to the lack of a fully human assay platform that can recapitulate monocyte-neural stem cell interactions within the CNS microenvironment. We therefore developed a human model system to assess the impact of monocytic factors on neural stem cells, establishing a high-content compatible assay for screening monocyte-induced neural stem cell proliferation and differentiation.

The Knowledge and Practices Toward Food Safety Measures at Home in the Lebanese Community.

Hygienic measures practiced at home are highly related to the occurrence of food-borne diseases during food production, storage, and handling. Contaminated food remains a major cause of several diarrheal diseases, hospitalizations, and spikes in medical expenses. In our current study, we aimed to assess the knowledge of food safety and the food safety and hygiene practices at home among the Lebanese population.

A Hybrid Redox-Mediated Zinc-Air Fuel Cell for Scalable and Sustained Power Generation.

Zinc-air batteries (ZABs) have attracted considerable attention for their high energy density, safety, low noise, and eco-friendliness. However, the capacity of mechanically rechargeable ZABs was limited by the cumbersome procedure for replacing the zinc anode, while electrically rechargeable ZABs suffer from issues including low depth of discharge, zinc dendrite and dead zinc formation, and sluggish oxygen evolution reaction, etc. To address these issues, we report a hybrid redox-mediated zinc-air fuel cell (HRM-ZAFC) utilizing 7,8-dihydroxyphenazine-2-sulfonic acid (DHPS) as the anolyte redox mediator, which shifts the zinc oxidation reaction from the electrode surface to a separate fuel tank.

Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications.

Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous system tumor with a poor prognosis. Potassium channels are grouped into four subfamilies differing by their domain structure, gating mechanisms, and functions. Pertinent literature indicates the vital functions of potassium channels in many aspects of glioma carcinogenesis, including proliferation, migration, and apoptosis.

Novel Biomarkers for Inflammatory Bowel Disease and Colorectal Cancer: An Interplay between Metabolic Dysregulation and Excessive Inflammation.

Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic states. Inflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic inflammation of the gastrointestinal tract, with evidence of subsequent metabolic syndrome disorder. Studies have demonstrated that as many as 42% of patients with ulcerative colitis (UC) who are found to have high-grade dysplasia, either already had colorectal cancer (CRC) or develop it within a short time.

Dyadic effects of interpersonal perception on the quality of couple relationships: Idealization and accuracy matter.

Interpersonal perceptions have an impact on the quality of couple relationships but we want to examine the putative moderating role of gender considering personal meanings as the target of perception. We employed the Couple's Grid to measure interpersonal perception based on personal constructs and the Actor-Partner Interdependence Model (pooled regression) to analyze the mutual effects of partners' observations. We explore the dyadic effects of seven variables of interpersonal perception on relationship quality in a sample of 26 Spanish opposite-sex couples.

The effect of two cognitive therapies on subjective wellbeing of individuals with depression: results from a randomised controlled trial.

Background: Despite the burden associated to depression, current standards of care are still limited in scope and effectiveness. In addition, therapy outcomes have frequently focused solely on symptoms, leaving patients' wellbeing relatively unaddressed.

Aims: The objective of this study was to test whether two cognitive therapies increased subjective wellbeing in a sample of adults diagnosed with a depressive disorder, additionally assessing the relationship between this growth and decreases in both depression severity and psychological distress.

High-Power Near-Neutral Aqueous All Organic Redox Flow Battery Enabled with a Pair of Anionic Redox Species.

Aqueous organic redox flow batteries (AORFBs) are regarded as a promising alternative for low-cost and durable grid-scale energy storage. However, the narrow potential gap, chemical lability and membrane fouling in most AORFBs constitute formidable roadblocks for practical applications. Herein, a pair of anionic organic molecules, namely (PPBPy)Br and PSS-TEMPO, are proposed.

Molecular engineering of dihydroxyanthraquinone-based electrolytes for high-capacity aqueous organic redox flow batteries.

Aqueous organic redox flow batteries (AORFBs) are a promising technology for large-scale electricity energy storage to realize efficient utilization of intermittent renewable energy. In particular, organic molecules are a class of metal-free compounds that consist of earth-abundant elements with good synthetic tunability, electrochemical reversibility and reaction rates. However, the short cycle lifetime and low capacity of AORFBs act as stumbling blocks for their practical deployment.

The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics.

The use of monoclonal antibodies represents an important and efficient diagnostic and therapeutic tool in disease management and modern science but remains limited by several factors including the uneven distribution in diseased tissues as well as undesired activation of side immune reactions. Major scientific advancements including Recombinant DNA Technology, Hybridoma Technology, and Polymerase Chain Reaction have considerably impacted the use of monoclonal antibodies providing technical and effective solutions to overcome the shortcomings encountered with conventional antibodies. Initially, the introduction of antibody fragments allowed a more uniform and deeper penetration of the targeted tissue and reduced unwanted activation of Fc-mediated immune reactions.

Cognitive-Behavioral and Personal Construct Therapies for Depression in Women with Fibromyalgia: A Randomized Controlled Trial.

Background/objective: Fibromyalgia is a chronic pain syndrome that depressive symptoms can aggravate. The aim of the present study was to test the efficacy of Personal Construct Therapy (PCT), an approach that emphasizes identity features and interpersonal meanings as the focus of the treatment of depressive symptoms, in women with fibromyalgia.

Method: We compared PCT with Cognitive Behavioral Therapy (CBT) in a multicenter parallel randomized trial.

Redox-Mediated Ambient Electrolytic Nitrogen Reduction for Hydrazine and Ammonia Generation.

This work presents a redox-mediated electrolytic nitrogen reduction reaction (RM-eNRR) using polyoxometalate (POM) as the electron and proton carrier which frees the TiO -based catalyst from the electrode and shifts the reduction of nitrogen to a reactor tank. The RM-eNRR process has achieved an ammonium production yield of 25.1 μg h or 5.

[Evidence-Based Psychological Treatments for Adults: A Selective Review].

Unlabelled: Evidence-Based Psychological Treatments for Adults: A Selective Review.

Background: Psychological treatments have shown their efficacy, effectiveness, and efficiency in dealing with mental disorders. However, considering the scientific knowledge generated in recent years, in the Spanish context, there are no updating studies about empirically supported psychological treatments.

Decoupled Redox Catalytic Hydrogen Production with a Robust Electrolyte-Borne Electron and Proton Carrier.

Electrolytic water splitting is an effective approach for H mass production. A conventional water electrolyzer concurrently generates H and O in neighboring electrode compartments separated by a membrane, which brings about compromised purity, energy efficiency, and system durability. On the basis of distinct redox electrochemistry, here, we report a system that enables the decoupling of both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) from the electrodes to two spatially separated catalyst bed reactors in alkaline solutions.

Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs.

Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most promising natural molecules in the prevention and treatment of chronic diseases and autoimmune disorders. One of the key limitations in the clinical use of resveratrol is its extensive metabolic processing to its glucuronides and sulfates.

Single-Molecule Redox-Targeting Reactions for a pH-Neutral Aqueous Organic Redox Flow Battery.

Aqueous organic redox flow batteries (AORFBs) have received considerable attention for large-scale energy storage. Quinone derivatives, such as 9,10-anthraquinone-2,7-disulphonic acid (2,7-AQDS), have been explored intensively owing to potentially low cost and swift reaction kinetics. However, the low solubility in pH-neutral electrolytes restricts their application to corrosive acidic or caustic systems.

Common and differential dimensions of personal identity between psychosis and depression: The relevance of gender and depressive mood.

Disturbances in personal identity are recognized in psychosis and depression. However, it is unknown whether these disruptions share common processes across clinical groups, or whether there are unique alterations by group or between men and women within each clinical group. To advance on this question, we compared personal identity dimensions in psychosis and depression and investigated the effects of gender and depressive mood.

Personal Construct Therapy vs Cognitive Behavioral Therapy in the Treatment of Depression in Women with Fibromyalgia: Study Protocol for a Multicenter Randomized Controlled Trial.

Unlabelled: Fibromyalgia (FM) is a debilitating syndrome, more prevalent in women, which is aggravated by the presence of depressive symptoms. In the last decade, cognitive behavioral therapy (CBT) has demonstrated to reduce such depressive symptoms and pain in these patients, but there are still a considerable number of them who do not respond to interventions. The complexity of the disorder requires the consideration of the unique psychological characteristics of each patient to attain good outcomes.

A molecular toolbox for studying protein degradation in mammalian cells.

Protein degradation is a crucial regulatory process in maintaining cellular proteostasis. The selective degradation of intracellular proteins controls diverse cellular and biochemical processes in all kingdoms of life. Targeted protein degradation is implicated in controlling the levels of regulatory proteins as well as eliminating misfolded and any otherwise abnormal proteins.

Calibration of mathematical water quality modeling in a river basin under critical conditions.

In order to assist with the management of water resources, this study aimed to calibrate the water quality model "Ottocoded Critical Basins Analysis" (ABaCO) in a section of the Lambari River, located in the city of Poços de Caldas, Minas Gerais, Brazil, and it is considered qualitatively critical by the "National Water Agency" (ANA). The calibration results, obtained automatically by the Microsoft Excel tool Solver, showed good adjustments between the simulated and observed concentrations for the following parameters: total nitrogen, organic phosphorus, inorganic phosphorus, and total phosphorus, considering a visual interpretation of the graphics. The other calibrated parameters (BOD, DO, organic nitrogen, ammoniacal nitrogen, and nitrate) obtained satisfactory adjustments.

For more than money: willingness of health professionals to stay in remote Senegal.

Background: Poor distribution of already inadequate numbers of health professionals seriously constrains equitable access to health services in low- and middle-income countries. The Senegalese Government is currently developing policy to encourage health professionals to remain in areas defined as 'difficult'. Understanding health professional's preferences is crucial for this policy development.

One-year follow-up of a randomized trial with a dilemma-focused intervention for depression: Exploring an alternative to problem-oriented strategies.

Background: Cognitive behavioural therapy (CBT) is aimed to counteract cognitions and behaviours that are considered as dysfunctional. The aim of the study is to test whether the inclusion of a non-counteractive approach (dilemma-focused intervention, DFI) in combination with CBT group therapy will yield better short- and long-term outcomes than an intervention conducted entirely using CBT.

Method: A total of 128 patients with depression and at least one cognitive conflict, of six health community centres in Barcelona, participated from November of 2011 to December of 2014 in seven weekly group CBT sessions and were then randomly allocated to either DFI or CBT (eight individual sessions each) by an independent researcher.