Publications by authors named "Salina Patel"
Article Synopsis
- Mycobacterium tuberculosis is a leading cause of global mortality, and to combat it effectively, improvements in diagnostics, drug regimens, and vaccinations are essential.
- The study investigates Furamidine, a compound that may enhance autophagy—a defense mechanism against pathogens—by evaluating its effects on tuberculosis bacteria within human cells.
- Findings demonstrate that Furamidine reduces mycobacterial growth and induces autophagy by affecting intracellular calcium levels and activating specific proteins, suggesting it could be a promising approach to improve TB treatment.
Drug-resistant tuberculosis (TB) outbreak has emerged as a global public health crisis. Therefore, new and innovative therapeutic options like host-directed therapies (HDTs) through novel modulators are urgently required to overcome the challenges associated with TB. In the present study, we have investigated the anti-mycobacterial effect of 4-(Benzyloxy)phenol.
View Article and Find Full Text PDFCytokine therapy and cytokine-mediated autophagy have been used as prominent host-directed therapy (HDT) approaches to restrain M. tb growth in the host cell. In the present study, we have dissected the anti-tubercular activity of Soybean lectin (SBL) through cytokine-mediated autophagy induction in differentiated THP-1 (dTHP-1) cells.
View Article and Find Full Text PDFAc-93253 inhibits intracellular growth of mycobacteria in human macrophages by inducing apoptosis in mitochondrial-dependent manner.
Biochim Biophys Acta Gen Subj
September 2023
Article Synopsis
- * The study specifically examines how the micromolecule Ac-93253 promotes apoptosis in immune cells without being toxic at low concentrations, while also affecting pro-apoptotic gene expression.
- * Results indicate that Ac-93253 effectively reduces mycobacterial growth in infected macrophages, suggesting that apoptosis is a key mechanism through which it exerts its antibacterial effects.
Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection.
Biochim Biophys Acta Mol Basis Dis
March 2023
Coronavirus disease 19 (COVID-19) is caused by a highly contagious RNA virus Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), originated in December 2019 in Wuhan, China. Since then, it has become a global public health concern and leads the disease table with the highest mortality rate, highlighting the necessity for a thorough understanding of its biological properties. The intricate interaction between the virus and the host immune system gives rise to diverse implications of COVID-19.
View Article and Find Full Text PDFThe weaponry possessed by Mycobacterium tuberculosis (M. tb) in the form of immunodominant antigens hijack the host immune system to give a survival advantage to this intracellular fiend, but the mechanism of this control is not entirely known. Since we have previously reported the mechanism of autophagy inhibition by early secreted antigenic target 6 kDa (ESAT-6) through microRNA (miR)-30a-3p in Calcimycin treated differentiated THP-1 (dTHP-1) cells, the present study was undertaken to deduce the effect of miR-30a on the immunomodulatory profile of ESAT-6 treated cells and the mechanism involved thereof, if any.
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