Publications by authors named "Salina Begum"
The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T cell-specific ASM overexpressing mice (t-ASM/CD4cre) to clarify the impact of cell-intrinsic ASM activity on T cell function and .
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- Morphological changes in astrocytes are linked to major depressive disorder (MDD), with evidence showing reduced blood vessel coverage by aquaporin-4 (AQP-4) in the prefrontal cortex of affected patients.
- In an animal model of depression, rats bred for high anxiety-like behavior displayed similar reductions in AQP-4-positive astrocyte processes compared to non-anxiety rats.
- Treatment with the antidepressant fluoxetine improved astrocyte plasticity and increased their processes in non-anxiety rats and restored Basal levels in high anxiety rats, but only if AQP-4 was present, indicating its crucial role in astrocyte function.