Cancer Stem Cell and Tumor Immune Microenvironment (TIME): Dangerous Crosstalk.

Cancer stem cells (CSCs) are the key drivers of tumorigenesis and relapse. A growing body of evidence reveals the tremendous power of CSCs to directly resist innate and adaptive anti-tumor immune responses. The immunomodulatory property gives CSCs the ability to control the tumor immune microenvironment (TIME).

Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis.

Myasthenia gravis (MG) is a rare autoimmune disease that affects the neuromuscular junction. It is characterized by the production of heterogeneous autoantibodies that bind to the neuromuscular junction and alter neural transmission. Recently, more attention was given to MG-related antibodies and their clinical influence.

Retraction (mal)practices of elite marketing and social psychology journals in the Dirk Smeesters' research misconduct case.

The Dirk Smeesters case is one of the most well-documented and widely publicized cases of research misconduct to date. We investigate, using a case study approach, which of Smeesters' articles were found to be unreliable and recommended for retraction, which were retracted, and which were not. We also investigate by whom, when, and how these fraudulent articles were retracted.

Pyrite Dissolution in the Cretaceous Yogou Formation of the Niger (Chad) Basin: Implications for Basin Evolution under a Rift Tectonic Setting.

This is the first study of pyrite minerals in the entire West and Central African Rift System (WCARS). Several polished organic-rich core samples from the Cretaceous Yogou Formation of the Niger (Chad) Basin located in the WCARS were investigated for their pyrite content using FE-SEM and SEM-EDS imaging techniques. An attempt was made to classify the types and provenance of the pyrites and to highlight the control of rift fractures on the oxidation and dissolution of pyrites in the region.

A bibliometric investigation of the journals that were repeatedly suppressed from Clarivate's Journal Citation Reports.

Journals indexed by Clarivate are temporarily suppressed from the Journal Citation Reports (JCR) if their Journal Impact Factor (JIF) scores are distorted through excessive self-citations or citation stacking with other journals. This paper reports the results of a bibliometric investigation that covers the 18 journals that were suppressed three or more times from the JCR. Results indicate that these 18 journals were repeatedly and exclusively suppressed for being excessive self-citers.

Immune response to COVID-19 infection: a double-edged sword.

COVID-19 global pandemic has not ceased to spread worldwide since December 2019. Today, scientists and healthcare workers are urgently working to stop this viral invasion and protect the world community. Deciphering the specific cellular and molecular immune response to the new coronavirus 2019 is an essential step in order to develop effective treatment and vaccine.

Detection of PIK3R1 (L449S) Mutation in a Patient with Ovarian Cancer: A Case Report.

Ovarian cancer (OC) is one of the most dangerous gynecological diseases and greatly increases the death risk worldwide. The heterogeneity of the ovarian tumors among patients and the lack of sufficient therapies for these tumors make the selection of the appropriate treatment a hard challenge. Understanding the mechanisms leading to OC becomes an urgent need in order to find out better therapeutic strategies.

RICTOR gene amplification is correlated with metastasis and therapeutic resistance in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, metastasis and lack of targeted therapies. Herein, we discuss the clinical, histopathological and genetic profile of a woman diagnosed with TNBC. Since the patient had no durable response to chemotherapy, a genetic profiling was carried out.