Should we still only rely on EDSS to evaluate disability in multiple sclerosis patients? A study of inter and intra rater reliability.

Background: Few studies assessed reliability and inter-rater variability of EDSS and functional parameters (FP) rating.

Objective: To evaluate inter-rater variability and errors in EDSS and FP rating in junior (JN) and MS Neurologists (MSN).

Method: Patients with MS were examined by a JN and a MSN on the same day.

Digital biomarkers can highlight subtle clinical differences in radiologically isolated syndrome compared to healthy controls.

Objective: To explore the use of digital biomarkers to distinguish healthy controls (HC) from subjects with a radiologically isolated syndrome (RIS).

Methods: We developed a smartphone application called MS Screen Test (MSST) to explore several dimensions of the neurological exam such as finger tapping speed, agility, hand synchronization, low contrast vision and cognition during a short evaluation. This app was tested on a cohort of healthy volunteers including a subset of subjects who underwent two evaluations on the same day to assess reproducibility.