Publications by authors named "Sali Merjanah"

Article Synopsis
  • Systemic lupus erythematosus (SLE) and myasthenia gravis (MG) are autoimmune diseases with suggested associations, potentially increasing SLE risk following thymectomy for MG.
  • A study analyzed large databases, including IBM Watson Health Explorys and the Million Veteran Program, revealing that individuals with MG were over 10 times more likely to develop SLE compared to those without MG.
  • The research confirmed a strong association between SLE and MG, particularly among younger, African American women, and highlighted that MG patients who underwent thymectomy were at an even higher risk for SLE.
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Objective: There is an increased risk of fracture in individuals with ankylosing spondylitis (AS) compared to the general population, possibly due to systemic inflammatory effects. The use of tumor necrosis factor inhibitors (TNFi) may reduce fracture risk by inhibiting inflammation. We assessed fracture rates in AS versus non-AS comparators and whether these rates have changed since the introduction of TNFi.

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Background: Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective is to study the prevalence of cancer in patients with AS in the US.

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The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients.

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Purpose Of Review: Axial spondyloarthritis (AxSpA) is a distinct clinical entity with characteristic clinical and radiographic features; however, a multitude of other metabolic, infectious and inflammatory disorders mimic it both clinically and radiographically.

Recent Findings: We present in this review article recent updates about the various disease entities and conditions that may mimic AxSpA and how to differentiate among them. The sensitivity and specificity of MRI in diagnosing AxSpA has limitations and needs to be interpreted in the context of the clinical picture.

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