Synthesis of 1,2,4-Trisubstituted-(1)-imidazoles through Cu(OTf)-/I-Catalyzed C-C Bond Cleavage of Chalcones and Benzylamines.

1,2,4-Trisubstituted-(1)-imidazoles have been synthesized by the Cu(OTf)- and I-catalyzed unusual C-C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C-C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1)-imidazoles.

Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors.

Obesity contributes to the genesis of many metabolic disorders including dyslipidemia, coronary heart disease (CHD), nonalcoholic fatty liver, type 2 diabetes, etc. Pancreatic lipase plays a vital role in food fat digestion and absorption. Therefore, to control obesity, inhibition of pancreatic lipase is the active therapy.