Publications by authors named "Salena S Von"
Frequent plateletpheresis is associated with severe lymphopenia of uncertain clinical significance. We assessed the functional impact of frequent platelet donations and associated lymphopenia on the response to neoantigens. We conducted a prospective study of 102 platelet donors (HIV uninfected) who were naive to meningococcal vaccination recruited at Brigham and Women's Hospital.
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- Phocaeicola vulgatus is a common bacterium in the human gut that produces a newly discovered antibacterial protein called BcpT, which is encoded on a mobile plasmid.
- BcpT needs to be cleaved at two specific sites to become active, and certain bacterial proteases are responsible for this activation.
- This toxin targets other bacteria by recognizing a specific receptor, leading to stress responses that prompt the expression of protective genes against various antimicrobial agents.
Mechanistic studies of anaerobic gut bacteria have been hindered by the lack of a fluorescent protein system to track and visualize proteins and dynamic cellular processes in actively growing bacteria. Although underappreciated, many gut "anaerobes" are able to respire using oxygen as the terminal electron acceptor. The oxygen continually released from gut epithelial cells creates an oxygen gradient from the mucus layer to the anaerobic lumen [L.
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