Publications by authors named "Salem T Daniel"
Article Synopsis
- Resistance to critical antibiotics like carbapenem and colistin poses a major global health risk, as highlighted by a study involving 583 isolates from humans, animals, and the environment in Nigeria.
- Among these isolates, 18.9% showed resistance to at least one type of carbapenem antibiotic, while 9.1% exhibited resistance to both carbapenems and colistin.
- Whole genome sequencing revealed novel mutations linked to this resistance, indicating that both humans and animals in Nigeria could be crucial in the spread of these resistant bacteria, underscoring the need for increased research on antimicrobial resistance in Africa.
Colistin is a last-resort drug used to treat infections caused by multidrug-resistant Gram-negative bacteria that have developed carbapenem resistance. Emergence and rapid dissemination of the nine plasmid-mediated mobile colistin resistance genes (mcr-1 to mcr-9) has led to fear of pandrug-resistant infections worldwide. To date, there is only limited information on colistin resistance in African countries where the drug is widely used in agriculture.
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