Effect of autologous fibrin glue on seroma reduction after modified radical mastectomy for breast cancer: A randomized controlled trial.

Introduction: Breast cancer stands out as the second most common cancer in the world with incidence 35.1% of all malignancies among females in Egypt. Fluid build-up after breast surgery is still the most annoying complication which leads to worse outcome.

Couple of graphene oxide and functionalized carbon nanotubes for dye degradation enhancement of anatase under visible light and solar irradiation.

Graphene oxide sheets (GO) were coupled with carbon nanotubes (CNTs) to enhance the photoactivity of anatase under visible and solar irradiation. The carbon nanotube surface was functionalized in the acidic reflux condition before coupling with GO and decoration of anatase by the sol-gel method. A modified kinetic model was appropriately applied to predict the breakthrough in the methylene blue degradation yield and determine the constant rate which was clearly affected by coupling architecture.

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial.

Staphylococcus aureus colonizes patients with atopic dermatitis (AD) and exacerbates disease by promoting inflammation. The present study investigated the safety and mechanisms of action of Staphylococcus hominis A9 (ShA9), a bacterium isolated from healthy human skin, as a topical therapy for AD. ShA9 killed S.

Crosstalk between miR-203 and PKCθ regulates breast cancer stem cell markers.

Introduction: Protein kinase C theta (PKCθ) is expressed in ER-negative breast cancer and promotes cancer stem cells (CSCs) phenotype. PKCθ gene (PRKCQ) is predicted to be a target for tumor suppressor miR-203. Herein, we aim to validate this prediction and evaluate the ability of miR-203 to inhibit migration of breast cancer cell line enriched with CSCs, MDA-MB-231, via PRKCQ targeting.

Ecofriendly novel synthesis of tertiary composite based on cellulose and myco-synthesized selenium nanoparticles: Characterization, antibiofilm and biocompatibility.

Microbial infections are considered common and dangerous for humans among other infections; therefore the synthesis of high efficacy antimicrobial and anti-biofilm composites is continuous to fight microbial resistance. In our study, a new and novel tertiary composite (TC) was synthesized, it composed of TEMPO cellulose (TOC), chitosan, starch, and myco-synthesized Se-NPs. Myco-synthesized Se-NPs and TC were fully characterized using UV, FT-IR, XRD, SEM with EDX, particle distribution, and mapping.

On-admission plasma levels of BNP, MR-proADM, and cTnI in pediatric heart failure: contributions to diagnosis, prognosis, and outcome.

Background: The aim of this study is to evaluate the use of on-admission plasma levels of BNP, MR-proADM, and cTnI in diagnosing the clinical severity and progression of heart failure (HF) in children with CHD. Also, to correlate the levels of these biomarkers with the HF outcome (survival versus in-hospital mortality).

Results: A prospective cohort study conducted in period from January 2017 to March 2018.

Intense pulsed light versus cryotherapy in the treatment of hypertrophic scars: A clinical and histopathological study.

Background: Different therapeutic modalities have been tried for hypertrophic scar treatment. To our knowledge, intense pulsed light (IPL) has not been previously evaluated in comparison with cryotherapy as a stand-alone treatment for hypertrophic scars.

Objective: We aimed to evaluate the efficacy of IPL as a monotherapy for hypertrophic scar treatment as compared with cryotherapy both clinically and histopathologically.

Detecting and Tracking the Positions of Wild Ungulates Using Sound Recordings.

Monitoring wild ungulates such as deer is a highly challenging issue faced by wildlife managers. Wild ungulates are increasing in number worldwide, causing damage to ecosystems. For effective management, the precise estimation of their population size and habitat is essential.

Antibacterial, Antiviral, and Self-Cleaning Mats with Sensing Capabilities Based on Electrospun Nanofibers Decorated with ZnO Nanorods and Ag Nanoparticles for Protective Clothing Applications.

The COVID-19 pandemic has clearly shown the importance of developments in fabrication of advanced protective equipment. This study investigates the potential of using multifunctional electrospun poly(methyl methacrylate) (PMMA) nanofibers decorated with ZnO nanorods and Ag nanoparticles (PMMA/ZnO-Ag NFs) in protective mats. Herein, the PMMA/ZnO-Ag NFs with an average diameter of 450 nm were simply prepared on a nonwoven fabric by directly electrospinning from solutions containing PMMA, ZnO nanorods, and Ag nanoparticles.

Social-ecological interactions in the Draa River Basin, southern Morocco: Towards nature conservation and human well-being using the IPBES framework.

Water is essential to human societies and a prerequisite for flourishing nature, especially in arid regions. Yet, climate change and socio-economic developments are expected to exacerbate current and future stresses on water resources, demanding innovative approaches to balance water needs for society and nature conservation. In this study, we use the IPBES conceptual framework to combine ecological and socio-economic insights and analyse the connections between people and nature in the water scarce Draa River Basin, southern Morocco.

Likelihood of pregnancy in cows identified with different amounts of anechoic intrauterine fluid at the time of insemination.

Effects of amount of anechoic intrauterine fluid (IUF) and size of largest follicle at insemination on proportion of cows pregnant as a result of AI (P/AI percentage), as well as factors associated with amount of IUF and size of the follicle were investigated. Follicle size was determined, and amount of IUF in the largest uterine segment was categorized as containing no fluid, ≤10, >10-20, and >20 mm using the ultrasonic monitor grid in 735 cows at time of insemination. Multivariable regression models were constructed to evaluate effects of different variables on P/AI percentage, and variables associated with the IUF score and follicle size.

Impact of miRNAs expression modulation on the methylation status of breast cancer stem cell-related genes.

Purpose: Altered miRNAs play a crucial role in the emergence of the breast cancer stem cell (BCSC) phenotype. The interplay between miRNAs and methylation enzymes has been documented. One of the most aggressive breast cancer cell lines, MDA-MB-231, has expressed much more DNMT3B than DNMT3A.

Reduced-intensity therapy for pediatric lymphoblastic leukemia: impact of residual disease early in remission induction.

Legacy data show that ∼40% of children with acute lymphoblastic leukemia (ALL) were cured with limited antimetabolite-based chemotherapy regimens. However, identifying patients with very-low-risk (VLR) ALL remains imprecise. Patients selected based on a combination of presenting features and a minimal residual disease (MRD) level <0.

The Prognostic Significance of 5-Fluorouracil Induced Inflammation and Immuno-Modulation in Colorectal Cancer Patients.

Aim: The change in the levels of peripheral inflammatory markers together with EGFR in relation to 5- fluorouracil (5-FU) therapy was evaluated for their prognostic significance in colorectal cancer (CRC) patients.

Patients And Methods: Expression levels of COX2, IL6, IL1β, EGFR, IL10, and TNFα were determined with quantitative real-time PCR (qPCR) in the peripheral blood of 90 CRC patients. The inflammatory response was correlated with patients' clinical features, disease-free survival (DFS), and overall survival (OS).

Effect of platelet-rich plasma on the outcome of mini-punch grafting procedure in localized stable vitiligo: Clinical evaluation and relation to lesional basic fibroblast growth factor.

Surgical methods are favorably used for treatment of stable vitiligo, and platelet-rich plasma (PRP) can be added to augment the effect. The additive value of PRP, however, remains elusive. Basic fibroblast growth factor (bFGF) is released from activated platelets with a capacity for stimulating melanocyte proliferation and migration.

Biomedical Applications of Mycosynthesized Selenium Nanoparticles Using Penicillium expansum ATTC 36200.

In this study, green and eco-friendly biosynthesis of selenium nanoparticles (Se-NPs) were performed using Penicillium expansum ATTC 36200 for multiple biomedical applications. Mycosynthesized Se-NPs were completely characterized using UV, FT-IR, XRD, SEM, and TEM techniques. Se-NPs biosynthesized by P.

Role of first-trimester three-dimensional (3D) power Doppler of placental blood flow and 3D placental volume in early prediction of pre-eclampsia.

Objective: To assess the efficacy of first-trimester three-dimensional (3D) placental volume as well as 3D power Doppler of placental vascular indices for early prediction of pre-eclampsia.

Methods: The prospective cohort study included over 2019 women with a singleton pregnancy in their first trimester at 11-13+ weeks of pregnancy. All women were examined by 3D abdominal ultrasound, including Doppler techniques for the placental volume and placental vascular indices.

Meta-analysis of Genetic Diversity of the VP1 Gene Among the Circulating O, A, and SAT2 Serotypes and Vaccine Strains of FMD Virus in Egypt.

Introduction: Three strains of the FMD virus (A, O, and SAT 2) were recognised as causes of the FMD circulating in Egypt. The aims of this study were to trace the FMDV isolates from outbreaks in Egypt to understand their epidemiology and evolution and to understand the situation of the vaccine strains compared with the circulating serotypes.

Material And Methods: A meta-analysis was carried out by using the data available for FMD outbreaks in Egypt from GenBank and the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD); a comparison was done with both data sets for the three serotypes.

Targeting Tau to Treat Clinical Features of Huntington's Disease.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by severe motor, cognitive and psychiatric impairments. While motor deficits often confirm diagnosis, cognitive dysfunctions usually manifest early in the disease process and are consistently ranked among the leading factors that impact the patients' quality of life. The genetic component of HD, a mutation in the huntingtin ( gene, is traditionally presented as the main contributor to disease pathology.

Can plastic waste management be a novel solution in combating the novel Coronavirus (COVID-19)? A short research note.

The year 2020 has been noted to be one of major calamity the world over, in which the majority of efforts in research and development have been dedicated towards combating the threat of the novel Coronavirus (COVID-19). Ever since the announcement of COVID-19 as a pandemic, such efforts were dedicated towards the research of its spread and vaccination. Yet still, the world might reach a resolution via an environmental solution that various entities have overlooked, with a plethora of environmental benefits vis-à-vis waste management.

Diversity in Androgen Receptor Action Among Treatment-naïve Prostate Cancers Is Reflected in Treatment Response Predictions and Molecular Subtypes.

Background: Metastatic prostate cancer (CaP) treatments are evolving rapidly but without evidence-based biomarkers to predict responses, and to maximize remissions and survival.

Objective: To determine the activity of androgen receptor (AR), the target for default first-line systemic treatment, in localized treatment-naïve CaP and its association with clinical risk factors, molecular markers, CaP subtypes, and predictors of treatment response.

Design Setting And Participants: We examined 452 bona fide AR target genes in clinical-grade expression profiles from 6532 such CaPs collected between 2013 and 2017 by US physicians ordering the Decipher RP test.

Solar treatment of sewage discharged from industrial estate for reduction of chemical oxygen demand over Degussa P-25 titania.

The aim of current investigation was to demonstrate the effectiveness of Degussa P-25 titania in the photocatalytic treatment of sewage, discharged from industrial estate, as a combined process under solar irradiation. The study was aimed to understand the role of fundamental factors including, titania load, initial COD level, and pH on the photocatalytic degradation rate. The commercially produced TiO represented a mesoporous structure, 2-30 nm, indicating the adequate activity in the COD reduction of sewages collected from the streams entreating anaerobic, aerobic, and sand filtration stages when 0.

Value of Galectin-3 assay in children with heart failure secondary to congenital heart diseases: a prospective study.

Background: Galectin-3 is a new biomarker, which plays an important role in tissue inflammation, cardiac remodeling, and fibrosis. It can be readily measured in the circulation to detect early heart failure (HF). This study aimed to assess the value of galectin-3 assay in early diagnosis of children with heart failure secondary to congenital heart disease (CHD) and correlate it with the patients' outcome.

From gangue to the fuel-cells application.

Hydrogen, which is a new clean energy option for future energy systems possesses pioneering characteristics making it a desirable carbon-free energy carrier. Hydrogen storage plays a crucial role in initiating a hydrogen economy. Due to its low density, the storage of hydrogen in the gaseous and liquids states had several technical and economic challenges.

Increasing Health Care Workers' Proficiency With Using Professional Medical Interpretation: A Workshop.

Introduction: Families with limited English proficiency are at risk for poor outcomes and medical errors due to barriers in communication. The use of professional medical interpretation has been linked to improved access to care, improved patient satisfaction, and better outcomes. However, medical interpretation remains underutilized, and the literature lacks guidelines for training health care workers in its use.