The rapid shallow breathing index (RSBI) as a predictor for extubation success in medical and surgical ICU patients: A retrospective cohort study.

Background: Endotracheal intubation and mechanical ventilation comprise common life support interventions for patients in intensive care units (ICUs). Premature or delayed extubation increases the risk of morbidity and mortality. Despite following weaning protocols, 10-20 % of patients fail extubation within 48 h.

Correction: From photocatalysis to photon-phonon co-driven catalysis for methanol reforming to hydrogen and valuable by-products.

Correction for 'From photocatalysis to photon-phonon co-driven catalysis for methanol reforming to hydrogen and valuable by-products' by Hui Wang , , 2025, https://doi.org/10.1039/d4cs00551a.

Anaesthetic efficacy of intraligamentary injection compared to incisive nerve block using 3% mepivacaine hydrochloride: a randomized clinical trial.

Background: In dentistry, local anesthetic is frequently used to manage pain throughout several phases of dental treatments, including tooth extraction. The study aimed to compare the effectiveness of two techniques for controlling pain during mandibular exodontia (tooth extraction), specifically focusing on the pain experienced during injection and extraction of mandibular anterior and premolars teeth. The two techniques being compared are the intraligamentary injection technique (ILI) and the incisive nerve block technique (INB).

Assessing clenbuterol's modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet.

This study was performed to reveal the metabolic effects and molecular mechanisms that govern the dietary incorporation of clenbuterol on growth performance, haemato-biochemical changes, histological alteration, and gene expression regulating glucose and lipid metabolism in normal and high-fat diets fed in Nile tilapia (Oreochromis niloticus). Six experimental diets were formulated, incorporating different concentrations of clenbuterol. The 1st three groups were supplemented with a diet comprising 6% fat, with clenbuterol of 0, 5, and 10 g/kg diet was designated as F6 clenb0, F6clenb5, and F6clenb10, respectively.

Single-cell atlas of the pregnant equine endometrium before and after implantation.

Embryo implantation in the mare occurs just over one month after fertilization, coinciding with the production of chorionic gonadotropin. The factors that regulate this late implantation in the mare, and whether they are unique to horses or shared with more invasive embryo implantation in other species, remain poorly understood. This study aimed to determine and compare the transcriptome and subpopulations of endometrial cells before and after embryo implantation in the horse.

Prevalence of physical and mental health problems among internally displaced persons in White Nile state, Sudan 2023: a cross sectional study.

Background: Following the latest war in 2023, over nine million people have been internally displaced, of which White Nile State received over 50,000. They lived in different camps and moved to big cities. This study assessed the scope of mental and physical concerns among the IDPs to identify important healthcare needs.

The efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers.

This study aimed to discover how using nano artichoke leaf extract Stabilized with zinc Nanoparticles (ZnO-Nano-ALPE) as an alternative to antibiotics and an antioxidant in broiler feed affected their growth, meat quality, and blood. In a completely randomized design experiment, 210 1-day-old chicks (Arbor Acres) were assigned to three trial groups. Each group was subdivided into seven replicates, each with ten unsexed chicks.

Association of plasma microRNAs with COVID-19 severity and outcome.

Objective: As one of the remarkable host responses to SARS-CoV-2 infection, circulating microRNAs (miRNAs) represent important diagnostic and prognostic diseases biomarkers. The study is a step towards highlighting the role of miRNAs in COVID-19 pathogenesis and severity.

Methods: In this case-control study, miRCURY LNA miRNA PCR plasma panel (168 miRNAs) was applied and the expression of the altered miRNAs was then analysed by quantitative real time PCR for 120 COVID-19 patients (30 mild, 30 moderate, 30 severe, and 30 critical) and 30 healthy subjects.

Digital dermatitis in dairy cattle in Egypt: Herd-level risk factors and Treponema spp. prevalence across lesion M-scores.

Digital dermatitis (DD) is an infectious disease of the digital skin of dairy cows that is associated with compromised animal welfare and significant economic losses. The hind feet of 16,098 dairy cows from 55 herds were examined in the milking parlor, and DD lesions identified were classified using the M-score system and swabbed for PCR testing. Swabs were also collected from hind feet with normal digital skin for comparison.

Retraction: Cefotaxime incorporated bimetallic silver-selenium nanoparticles: promising antimicrobial synergism, antibiofilm activity, and bacterial membrane leakage reaction mechanism.

[This retracts the article DOI: 10.1039/D2RA04717A.].

Introduction of a small volume ethyl acetate based liquid-liquid extraction procedure for analysis of polycyclic aromatic hydrocarbons in wastewater by atmospheric pressure gas chromatography-mass spectrometry and evaluation of method greenness.

The Small Volume Ethyl Acetate based Liquid-Liquid Extraction (SVEA-LLE) method, using Atmospheric Pressure Gas Chromatography-Mass Spectrometry (APGC-MS/MS) with Dual Head Robotic Tool Change (DH-RTC) Prep and Load (PAL) autosampler, was evaluated for the analysis of 17 PAHs in water and wastewater. The extraction method was first evaluated for extraction efficiency with respect to time using a one-way Analysis of Variance (ANOVA) and the effect of acidification. Method validation was performed as per SANTE/11312/2021 v2 2024 for analysis of PAHs in wastewater.

Mining contextually meaningful subgraphs from a vertex-attributed graph.

Networks have emerged as a natural data structure to represent relations among entities. Proteins interact to carry out cellular functions and protein-Protein interaction network analysis has been employed for understanding the cellular machinery. Advances in genomics technologies enabled the collection of large data that annotate proteins in interaction networks.

The circulatory levels and bone expression of MIR21, 34a, 155 and their target genes in a section of Egyptian Population.

Bone tissue is constantly regenerated and repaired through a finely balanced process known as bone remodeling. Many miRNAs act as regulators of the signaling pathways involved in bone metabolic processes to maintain tissue homeostasis. This study aimed to assess the circulating levels of MIR21, MIR34a, and MIR155 in human serum and their bone expression, and the expression of bone turnover-related genes which can reflect the bone quality.

Green synthesis of selenium nanoparticles from Cassia javanica flowers extract and their medical and agricultural applications.

Nanostructured materials are advantageous within numerous fields of medicine owing to their intriguing qualities, which include their size, reactive surface, bioactivity, potential for modification, and optical characteristics. Cassia javanica flower extract was used as a chelating agent in an environmentally friendly process to create SeNPs FTIR, XRD, and TEM, SAED were utilized to analyze and characterize the synthesized. The findings showed that the MIC of Se NPs against B.

Treatment effect modifiers of immunotherapies for relapsing-remitting multiple sclerosis-A systematic review and meta-analysis.

Background: This meta-analysis aimed to assess the treatment effects of immunotherapies in subgroups of adults with clinically isolated syndrome or relapsing forms of multiple sclerosis (MS) and the effect of potential treatment effect modifiers (TEMs).

Methods: Phase 2 and 3 RCTs with a placebo comparator were analyzed. Risk of bias was assessed.

Clean-up of wastewater discharged from zinc industry through application of zeolite 4A produced from a waste contaminated by lubricant oil components.

The zeolite 4 A powders were sustainably derived from clay-based waste contaminated with the spent lubricant oil. Then, the products were used to treat the wastewater discharged from a local zinc industry. The main challenge is removal of toxic organic components from the waste and conversion of obtained precursor to the zeolite structure, simultaneously.

Importance of RNase monitoring during large-scale manufacturing and analysis of mRNA-LNP based vaccines.

Ribonucleases (RNases) are ubiquitous in nature, being able to cleave a wide range of polyribonucleotides. While the presence of microbial and viral contamination in sterile manufacturing is highly studied and controlled, there are no standardized practices for evaluating RNase in the production facility. Since the COVID-19 pandemic, mRNA-LNP based vaccines have become part of routine large-scale manufacturing.

Investigating the in vitro antibacterial, antibiofilm, antioxidant, anticancer and antiviral activities of zinc oxide nanoparticles biofabricated from Cassia javanica.

It is thought to be risk-free, environmentally benign, and safe for biological processes to produce zinc oxide nanoparticles from renewable resources. This study examined Cassia javanica's ability to create ZnONPs. The generated ZnONPs were analyzed using a variety of techniques, such as TEM, FTIR spectroscopy, UV-Vis spectroscopy, and XRD analysis.

Unveiling the Neem () Effects on Biofilm Formation of Food-Borne Bacteria and the Potential Mechanism Using a Molecular Docking Approach.

Biofilms currently represent the most prevalent bacterial lifestyle, enabling them to resist environmental stress and antibacterial drugs. Natural antibacterial agents could be a safe solution for controlling bacterial biofilms in food industries without affecting human health and environmental safety. A methanolic extract of (neem) leaves was prepared and analyzed using gas chromatography-mass spectrometry for the identification of its phytochemical constituents.