Incidence of Uveitis Following Initiation of Prostaglandin Analogs Versus Other Glaucoma Medications: A Study from the SOURCE Repository.

Purpose: To evaluate the risk of incidence rates of uveitis among patients starting topical glaucoma therapy.

Design: Retrospective database study utilizing the Sight Outcomes Research Collaborative (SOURCE) Ophthalmology Data Repository.

Participants: Adult glaucoma patients who were recently started on topical glaucoma therapy.

Evaluation of Sociomedical Factors on Corneal Donor Recovery Using Machine Learning.

Purpose: To evaluate co-morbid sociomedical conditions affecting corneal donor endothelial cell density and transplant suitability.

Method(s): Corneal donor transplant information was collected from the CorneaGen eye bank between June 1, 2012 and June 30, 2016. A natural language processing algorithm was applied to generate co-morbid sociomedical conditions for each donor.

Using Natural Language Processing to Identify Different Lens Pathology in Electronic Health Records.

Purpose: Nearly all published ophthalmology-related Big Data studies rely exclusively on International Classification of Diseases (ICD) billing codes to identify patients with particular ocular conditions. However, inaccurate or nonspecific codes may be used. We assessed whether natural language processing (NLP), as an alternative approach, could more accurately identify lens pathology.

Repeatability and reliability of semi-automated anterior segment-optical coherence tomography imaging compared to manual analysis in normal and keratoconus eyes.

Purpose: To assess the repeatability and reliability of semi-automated EyeMark Python program measurements compared to manual ImageJ image processing of anterior segment-optical coherence tomography (AS-OCT) structures in healthy and keratoconus eyes.

Methods: Heidelberg AS-OCT was used to image 25 eyes from 14 healthy subjects and 25 eyes from 15 subjects with keratoconus between the ages of 20 and 80 years, collected prospectively, in this observational case-control study. Visual axis scan containing vertical fixation light beam was selected from the 15-line AS-OCT scan raster.

Association Between Socioeconomic Deprivation and Orbital Trauma in a Hospital-Based Population.

Purpose: To examine the association between area-level socioeconomic deprivation and orbital trauma among emergency ophthalmology consults.

Methods: We conducted a cross-sectional study using 5-year Epic data for all hospital-based ophthalmology consults at the University of Maryland Medical System, and the Distressed Communities Index (DCI) data for area-level socioeconomic deprivation. We ran multivariable logistic regression models adjusting for age to compute odds ratios (OR) and 95% confidence intervals (CI) for the association between the DCI quintile 5 distressed score and orbital trauma.

Weather Patterns and the Frequency of Ophthalmology Consultations in the Emergency Setting.

Purpose: To determine if weather patterns are associated with the frequency of ophthalmology consultations in the Emergency Room (ER) and trauma settings.

Methods: Hospital-based ophthalmology consultations between January 1, 2015 and December 31, 2020 at the University of Maryland Medical Center (UMMC) were included in the BALCITE (BALtimore Consultation, Inpatient, and Trauma of the Eye) database. Encounters were filtered to the general ER, the R.

Characteristics of Semiautomated Endothelial Cell-Density Measurements Among Corneal Donor Eyes.

Importance: Endothelial cell density in corneal donor eyes remains a critical component in selecting tissue suitable for corneal transplant.

Objective: To describe an anomaly in endothelial cell density discovered in a large cohort of corneal donor eyes.

Design, Setting, And Participants: Donor information for this cross-sectional study was obtained from the CorneaGen eye bank for donors from June 1, 2012, to June 30, 2016.

Inter-rater Reliability and Repeatability of Manual Anterior Segment Optical Coherence Tomography Image Grading in Keratoconus.

Objectives: To determine the repeatability of corneal measurements from anterior segment optical coherence tomography (AS-OCT) images using ImageJ software in healthy eyes compared with eyes with keratoconus.

Methods: Anterior segment OCT images of 25 eyes from 14 healthy subjects and 25 eyes from 15 subjects with keratoconus between the ages of 20 and 80 years were evaluated. Two trained observers used ImageJ to measure the central corneal cross-sectional area and anterior and posterior corneal arc lengths.

Estimated Prevalence of Keratoconus in the United States From a Large Vision Insurance Database.

Purpose: To estimate the prevalence of keratoconus in the United States using a large vision insurance database.

Methods: We used data from the 2016 vision service plan (VSP) Global claims database to estimate the prevalence of keratoconus among enrollees by state. The VSP Global database includes cross-sectional de-identified claims data summarized by state of residence in predefined age and gender groups.

Effect of Body Refrigeration Time on Cornea Donor Tissue.

Purpose: To determine how early body refrigeration affects corneal donor transplant suitability and endothelial cell density.

Methods: Donor information was obtained from the CorneaGen Eye Bank including demographics, time of death to preservation, and body refrigeration status, for donors between 2012 and 2016. The death to preservation interval was classified into 3 categories: 0 to 10, 10 to 20, and 20+ hours.

A review of imaging modalities for detecting early keratoconus.

Objectives: Early identification of keratoconus is imperative for preventing iatrogenic corneal ectasia and allowing for early corneal collagen cross-linking treatments to potentially halt progression and decrease transplant burden. However, early diagnosis of keratoconus is currently a diagnostic challenge as there is no uniform screening criteria. We performed a review of the current literature to assess imaging modalities that can be used to help identify subclinical keratoconus.

A Review of Ocular Graft-Versus-Host Disease.

: Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic hematopoietic stem cell transplantation, which is a potential curative therapy used in a variety of malignant or benign hematological diseases. Graft-versus-host disease primarily occurs in many organs, but most notably in the skin, lungs, gastrointestinal tract, liver, eyes, mucosa, and musculoskeletal system. Ocular manifestations of GVHD may precede other systemic GVHD findings, and it may be a poor prognosis for mortality.