Polymorphic properties and dissolution profile of efavirenz due to solvents recrystallization.

Polymorphism occurs in pharmaceutical compounds affect to the physicochemical quality and goal of therapy. Thus, quality evaluation of different crystal forms should be assessed especially the solubility and dissolution behaviors among polymorphic forms, which correlate to bioavailability and therapy efficacy. To achieved the different of a polymorph various solvent were used such as acetonitrile, methanol, ethyl acetate, acetone, water, n-hexane, and n-heptane.

Physicochemical and mechanical properties of paracetamol cocrystal with 5-nitroisophthalic acid.

We report novel pharmaceutical cocrystal of a popular antipyretic drug paracetamol (PCA) with coformer 5-nitroisophhthalic acid (5NIP) to improve its tabletability. The cocrystal (PCA-5NIP at molar ratio of 1:1) was synthesized by solvent evaporation technique using methanol as solvent. The physicochemical properties of cocrystal were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), fourier transform infrared spectroscopy (FTIR), hot stage polarized microscopy (HSPM) and scanning electron microscopy (SEM).

The improvement of ibuprofen dissolution rate through microparticles spray drying processed in an aqueous system.

A study to enhance the dissolution rate of ibuprofen, a poorly water-soluble drug, was carried out through combining specific formulations and processes with the addition of a hydrophilic carrier for the preparation of microparticles. Microparticle production was performed by spray drying ibuprofen microsuspensions formulated in an aqueous system with the addition of ethanol containing Aerosil 200 and Tween 80. We were able to consistently produce microparticles as much as 40% of the dry weight of the input microsuspension.