The main issues with current and traditional cancer therapy delivery systems include a lack of selectivity towards tumors, causing harm to healthy cells, low efficiency in loading drugs, and the inability to visually track the drug's localization after administration. These limitations negatively impact the effectiveness of therapy and result in increased treatment costs. Furthermore, conventional cancer therapies typically target tumor cells through a single mechanism, which eventually leads to the emergence of drug resistance.
View Article and Find Full Text PDFDue to the prevalence of drug-resistant bacteria and the ongoing shortage of novel antibiotics as well as the challenge of treating breast cancer, the therapeutic and clinical sectors are consistently seeking effective nanomedicines. The incorporation of metal oxide nanoparticles with biological macromolecules and an organic compound emerges as a promising strategy to enhance breast cancer treatment and antibacterial activity against drug-resistant bacteria in various biomedical applications. This study aims to synthesize a unique nanocomposite consisting of CeO embedded with folic acid and carboxymethyl cellulose (CFC NC) via a green precipitation method using Moringa oleifera.
View Article and Find Full Text PDFBackground: Biochar, a carbon-rich source and natural growth stimulant, is usually produced by the pyrolysis of agricultural biomass. It is widely used to enhance plant growth, enzyme activity, and crop productivity. However, there are no conclusive studies on how different levels of biochar application influence these systems.
View Article and Find Full Text PDFFinger millet, an important 'Nutri-Cereal' and climate-resilient crop, is cultivated as a marginal crop in calcareous soils. Calcareous soils have low organic carbon content, high pH levels, and poor structure. Such a situation leads to poor productivity of the crop.
View Article and Find Full Text PDFThe production of citric acid, a vital agricultural commodity utilized across various industries such as food, beverages, pharmaceuticals, agriculture, detergents, and cosmetics, predominantly relies on microbial fermentation, with accounting for approximately 90% of global production. In this study, we aimed to optimize the key factors influencing citric acid production, with a focus on strains, fermentation techniques, and carbon sources, particularly sugarcane molasses. , sourced from the Botany department/Biotechnology laboratories at Govt.
View Article and Find Full Text PDFThe genus holds economic significance due to its widespread distribution and diverse applications, including biological control, enzyme production, and various biotechnological uses. The accurate identification of species is crucial given their close association with human activities. Despite previous efforts in classification, a comprehensive analysis combining morphological and molecular approaches is necessary.
View Article and Find Full Text PDFStevia rebaudiana (stevia) is a plant in the Asteraceae that contains several biologically active compounds including the antidiabetic diterpene glycosides (e.g. stevioside, rebaudioside and dulcoside) that can serve as zero-calorie sugar alternatives.
View Article and Find Full Text PDFSalinity stress can significantly delay plant growth. It can disrupt water and nutrient uptake, reducing crop yields and poor plant health. The use of strigolactone can be an effective technique to overcome this issue.
View Article and Find Full Text PDFGlobally, salinity is an important abiotic stress in agriculture. It induced oxidative stress and nutritional imbalance in plants, resulting in poor crop productivity. Applying silicon (Si) can improve the uptake of macronutrients.
View Article and Find Full Text PDFDrought stress poses a significant challenge to maize production, leading to substantial harm to crop growth and yield due to the induction of oxidative stress. Deashed biochar (DAB) in combination with carboxymethyl cellulose (CMC) presents an effective approach for addressing this problem. DAB improves soil structure by increasing porosity and water retention and enhancing plant nutrient utilization efficiency.
View Article and Find Full Text PDFKam Sweet Rice is a high-quality local variety of Guizhou province in China, but most varieties have awns on lemma. In this study, we aimed to obtain awnless varieties of Kam Sweet Rice by blocking the awn development-related gene OsGAD1 using CRISPR/Cas9 technology. We determined that natural variations of the OsGAD1 triggered different lengths of awns of Kam Sweet Rice.
View Article and Find Full Text PDFThe deleterious impact of osmotic stress, induced by water deficit in arid and semi-arid regions, poses a formidable challenge to cotton production. To protect cotton farming in dry areas, it's crucial to create strong plans to increase soil water and reduce stress on plants. The carboxymethyl cellulose (CMC), gibberellic acid (GA) and biochar (BC) are individually found effective in mitigating osmotic stress.
View Article and Find Full Text PDFMaize cultivated for dry grain covers approximately 197 million hectares globally, securing its position as the second most widely grown crop worldwide after wheat. Although spermidine and biochar individually showed positive impacts on maize production in existing literature, their combined effects on maize growth, physiology, nutrient uptake remain unclear and require further in-depth investigation. That's why a pot experiment was conducted on maize with spermidine and potassium enriched biochar (KBC) as treatments in Multan, Pakistan, during the year 2022.
View Article and Find Full Text PDFHeavy metal cadmium (Cd) naturally occurs in soil and is a hazardous trace contaminant for humans, animals, and plants. The main sources of Cd pollution in soil include overuse of phosphatic fertilizers, manure, sewage sludge, and aerial deposition. That's why an experiment was conducted to analyze the effect of Cd toxicity in Capsicum annuum L.
View Article and Find Full Text PDFChromium (Cr) toxicity significantly threatens sunflower growth and productivity by interfering with enzymatic activity and generating reactive oxygen species (ROS). Zinc quantum dot biochar (ZQDB) and arbuscular mycorrhizal fungi (AMF) have become popular to resolve this issue. AMF can facilitate root growth, while biochar tends to minimize Cr mobility in soil.
View Article and Find Full Text PDFHepatitis C virus (HCV) causes various liver complications, including fibrosis, cirrhosis, and steatosis, and finally progresses toward hepatocellular carcinoma (HCC). The current study aimed to explore the antiviral activity of the traditional Pakistani medicinal plant () known as black willow against the hepatitis C virus (HCV). The anti-HCV activity of was established against stable Hep G2 cell lines expressing the HCV NS3 gene.
View Article and Find Full Text PDFIn the present study, the efficacy of one-step direct transesterification (OSDT) and Dual-step extraction-transesterification (DSET) of Chlorococcum sp., Nannochloropsis sp., and their consortium was evaluated for fatty acid methyl ester (FAME) yield.
View Article and Find Full Text PDFDrought and cadmium (Cd) stress are both major issues that significantly affect the growth and development of wheat plants. Both drought stress and Cd toxicity disrupt physiological processes i.e.
View Article and Find Full Text PDFDriven by the imperative need for sustainable and biodegradable materials, this study focuses on two pivotal aspects: cellulose extraction and dye removal. The alarming repercussions of non-biodegradable food packaging materials on health and the environment necessitate the exploration of viable alternatives. Herein, we embark on creating easily degradable biopolymer substitutes, achieved through innovative crafting of a biodegradable cellulose sheet sourced from extracted cellulose.
View Article and Find Full Text PDF