The impact of COVID-19 infection on thyroid function.

Extensive research on COVID-19 has revealed a notable link between the disease and thyroid disorders, highlighting complex interactions between thyroid hormones, immunomodulatory signaling molecules within the thyroid gland, and viral infections. This study evaluated the relationship between thyroid function and COVID-19 in Iraqi patients at Adiwaniyah Teaching Hospital. The cohort for this investigation comprised all patients who were admitted to the isolation center at the Teaching Hospital during the timeframe extending from January 2024 to June 2024.

Tailored Hydration for the Prevention of Contrast-Induced Acute Kidney Injury After Coronary Angiogram or PCI: A Systematic Review and Meta-Analysis.

Background: Contrast-induced acute kidney injury (CI-AKI) is a frequent complication of coronary interventions associated with an increased risk of mortality and morbidity. The optimal intravenous hydration strategy to prevent CI-AKI is not well-established. The primary objective is to determine if a tailored hydration strategy reduces the risk of CI-AKI and of major adverse cardiovascular events (MACE) in patients undergoing coronary angiography compared with a non-tailored hydration strategy.

Comparison of Alcohol Septal Ablation With Mavacamten in Obstructive Hypertrophic Cardiomyopathy.

Obstructive hypertrophic cardiomyopathy (HCM) is associated with significant morbidity attributed to left ventricular outflow tract (LVOT) obstruction. Although alcohol septal ablation (ASA) is an established interventional treatment, mavacamten, a novel cardiac myosin inhibitor, has emerged as a noninvasive pharmacologic alternative. Understanding the comparative efficacy of these 2 treatments is important for optimizing patient care.

Diosmin and Coenzyme q10: Synergistic histopathological and functional protection against doxorubicin-induced hepatorenal injury in rats.

Doxorubicin (DOX) is a cytotoxic anthracycline used to treat a variety of cancers. Cardiotoxicity, hepatotoxicity, and nephrotoxicity are adverse effects of DOX, that limit prognosis. The study aims to determine if diosmin (DIOS) and coenzyme Q10 (CoQ10) alone or in combination protect rats against DOX-induced liver and kidney damage.

Managing Left Ventricular Outflow Tract Obstruction in Combined Aortic Stenosis and Hypertrophic Cardiomyopathy.

This study presents an elderly man with sequential hemodynamic obstructions caused by hypertrophic cardiomyopathy and aortic stenosis. Septal reduction therapy was performed to avoid outflow tract obstruction associated with potential future transcatheter aortic valve replacement. This case highlights the importance of resolving outflow tract obstruction during assessment of aortic valve disease.

Virtual surgical planning in microsurgical head and neck reconstruction: The Newcastle experience.

Head and neck microvascular reconstruction is a complex but powerful tool following immediate cancer ablation or delayed sequalae after cancer treatment. Virtual surgical planning (VSP), using computer-aided design or computer-aided manufacturing has emerged as a potentially beneficial adjunct to head and neck reconstruction. The aim of this study was to assess the outcomes of VSP technology using the KLS Martin custom-made cutting guides and low-profile plates in head and neck microvascular reconstruction in our centre.

Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis.

This study evaluated the beneficial effects of chrysin against cyclophosphamide (CP)-induced testicular toxicity in rats across several parameters, including hormones, oxidative stress, inflammation, apoptosis, and protein expression. Rats were pretreated with oral doses of chrysin at 25, 50, or 100 mg/kg daily for 7 days. On the 8th day, all groups except controls received CP (200 mg/kg) injection.

A systematic approach for estimating colloidal particle adsorption model parameters.

The estimation of ion-exchange chromatography model parameters is crucial to enable efficient model-assisted biopharmaceutical downstream process development. Model calibration methods can be hindered by model limitations combined with parameter correlations, leading to time-consuming repeated parameter estimations. While Steric Mass Action isotherm estimation methods exist, there is a need for a systematic approach to estimate model parameters for an emerging Colloidal Particle Adsorption (CPA) model proposed by Briskot et al.

Radiological Diagnosis and Emergency Management of Aortic Dissection in a Patient With a Fused Bicuspid Aortic Valve: A Case Study.

 This report presents a case of an acute Type A aortic dissection in a young patient with atypical symptoms, highlighting the importance of prompt radiology-aided diagnosis and intervention. A 29-year-old male with no significant medical history presented with right upper quadrant and epigastric pain, along with leg numbness. Extensive imaging revealed an ascending aortic dissection with a 5.

Changes in central venous-to-arterial PCO difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients: a pot-hoc analysis of a multi-center prospective study.

Background: The main aim of the study whether changes in central venous-to-arterial CO difference (ΔP(v-a)CO) and central venous oxygen saturation (ΔScvO) induced by volume expansion (VE) are reliable parameters to define fluid responsiveness (FR) in sedated and mechanically ventilated septic patients. We also sought to determine whether the degree of FR was related to baseline ScvO and P(v-a)CO levels.

Methods: This was a post-hoc analysis of a multicenter prospective study.

Acrylamide-induced hypothalamic-pituitary-gonadal axis disruption in rats: Androgenic protective roles of apigenin by restoring testicular steroidogenesis through upregulation of 17β-HSD, CYP11A1 and CYP17A1.

Acrylamide (ARL) exposure induces significant toxicity to the hypothalamic-pituitary-gonadal (HPG) axis, leading to detrimental effects on behavior, neuroendocrine functions, steroidogensis, oxidative stress, inflammation, hormonal balance, sperm quality, and histopathological integrity in rats. This study investigates the protective role of oral apigenin (API; 10 or 20 mg/kg/day for 28 days) against ARL-induced toxicity in the HPG axis of male Wistar rats. Behavioral assessments revealed that ARL exposure impaired motor coordination and balance, as evidenced by increased landing foot splay distance and gait score.

Neuroprotective Effects of Trimetazidine against Cisplatin-Induced Peripheral Neuropathy: Involvement of AMPK-Mediated PI3K/mTOR, Nrf2, and NF-B Signaling Axes.

Cisplatin-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cisplatin chemotherapy used in cancer treatment. This study explored the neuroprotective effects of Trimetazidine (TRI) against CIPN by preserving nerve integrity, reducing neuro-oxidative stress, and alleviating neuroinflammation. Using a rat model of CIPN, we evaluated TRI's impact on motor coordination, pain sensitivity, and peripheral nerve histopathology.

Synergistic impact of nano-supramolecular coordination polymer based on cadmium, ethyl nicotinate and thiocyanate ligands as efficient catalyst to remove harmful elements from wastewater.

Under ultrasonication, cadmium nitrate tetrahydrates, ethyl nicotinate (EN), and potassium thiocyanate as connecting ligand self-assembled to form the nanosized supramolecular coordination polymer (NSCP1) and the crystalline supramolecular coordination polymer (SCP1) [Cd(EN)(SCN)]. Single crystal SCP1 X-ray diffraction (XRD) revealed that Cd has an octahedral shape. The network structure of SCP1 is composed of chair conformation cyclic [Cd(SCN)] building blocks that form a one dimensional (1D) chain with bilaterally coordinated EN.

Estimation of radiological health risks due to Ra, Th, and K in foods consumed in Iraqi Kurdistan Region.

This study investigates the activity concentration of natural radionuclides in a diverse range of food samples in the Koya district markets food baskets, including both domestic and imported products. The samples cover annual crops (e.g.

Seizure recurrence following the first unprovoked seizure: Risk factors among children in UAE.

In a retrospective study of paediatric and adolescent patients in Abu Dhabi, UAE, who experienced their first unprovoked seizure between March 2016 and March 2020, with a minimum one-year follow-up, we identified significant risk factors associated with seizure recurrence. Among 317 patients, 96.2% experienced seizure recurrence, with the majority (68.

Promoting health information system in guiding decisions for improving performance: an intervention study at the Research Institute of Ophthalmology, Giza, Egypt.

Objectives: This study aims to design and test a platform of key performance indicators (KPIs) and indices emphasizing achievements and improvement and helping decision-making.

Methods: An operations research study was designed to analyze data from the Hospital Management Information System (HMIS) from July 2017 to June 2018 at the Research Institute of Ophthalmology (RIO), Giza, Egypt. The HMIS data were submitted to reform covering parameters in service delivery and corresponding indicators and indices.

Erratum: An HPLC-SEC-based rapid quantification method for vesicular stomatitis virus particles to facilitate process development.

[This corrects the article DOI: 10.1016/j.omtm.

Classification of Alzheimer disease using DenseNet-201 based on deep transfer learning technique.

Alzheimer's disease (AD) is a brain illness that causes gradual memory loss. AD has no treatment and cannot be cured, so early detection is critical. Various AD diagnosis approaches are used in this regard, but Magnetic Resonance Imaging (MRI) provides the most helpful neuroimaging tool for detecting AD.

L-Arginine-induced acute pancreatitis and its associated lung injury in rats: Down-regulation of TLR-4/MAPK-p38/JNK signaling pathway via extract EGb 761.

Objectives: Acute pancreatitis (AP) is an abrupt inflammatory condition characterized by a storm of inflammatory cytokines leading to high morbidity and mortality. The current study aimed to examine the efficacy of extract EGb 761 (GBE) in the treatment of L-arginine-induced AP and its associated lung injury.

Materials And Methods: Forty rats were randomly assigned into four groups.

Potential association between COVID-19 infections and the declining incidence of lung cancers.

Background: The COVID-19 pandemic has significantly impacted global health and prompted studies on its effects across various diseases. Recent data suggest a potential correlation between COVID-19 and a decrease in lung cancer incidence. This study examines the association between COVID-19 infection and changes in lung cancer cases.