Tests and estimates (transmission disequilibrium test) for allelic association of CCR5delta32 with asthma in high-risk families.

Objective: To examine the possible associations between CCR5delta32 and asthma and related phenotypes in high-risk families.

Methods: A total of 154 families (453 individuals), with at least two affected children with physician-diagnosed asthma (PDA) and atopy defined as one or more skin prick test to common inhaled allergen (SPT wheal > or = 3 mm), were studied. Samples were genotyped using PCR assay and tested for possible associations by TDT and PDT and case control analyses.