A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India.

Chronic alcohol consumption is reported to be associated with increase in plasma homocysteine levels which is further influenced by the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene. The present study aims to understand the extent of the MTHFR C677T polymorphism in alcohol dependent (AD) cases of Meiteis of Manipur, a Mendelian population of India. MTHFR C677T polymorphism was screened in 313 controls and 139 alcohol dependent (AD) cases who all met DSM-IV criteria for alcohol dependence.

MTHFR C677T polymorphism among Meiteis of Manipur (India).

Background: The enzyme MTHFR catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which serves as a methyl donor in the reaction converting homocysteine to methionine. Mutation at MTHFR gene (C677T) has been implicated in the pathogenesis of common complex diseases such as thrombosis, hypertension, stroke, myocardial infarction, and recurrent pregnancy loss across world populations.

Objective: We wanted to explore C677T mutation among Meiteis of Manipur to generate baseline data and to gain information that could be used in disease prevention programs.

The association of non-HDL cholesterol with the presence of metabolic syndrome in North Indian subjects with and without CAD.

Aim: The present study aims to identify which lipid parameter is significantly associated with Coronary Artery Disease (CAD) and metabolic syndrome (MetS) and also to find out the association of non-HDL cholesterol (non-HDL-C) with the presence of MetS in North Indian subjects with and without CAD.

Subjects And Methods: One hundred and thirteen CAD and 140 non-CAD (controls) aged 35-75 years were recruited for the study, matched for ethnicity and geography after obtaining their written informed consent. The CAD patients were identified based on their medical diagnostic history.

Prevalence of MTHFR, Factor V, ACE and APOE gene polymorphisms among Muslims of Manipur, India.

Background: Chronic metabolic disorders such as cardiovascular disease and diabetes have become an emerging public health problem in India, in both rural and urban settings. Genetic markers like MTHFR, FV, ACE and APOE are important candidates involved in the development of these disorders.

Aim: The present study aims to understand the distribution of allele frequencies of the SNPs in the above-mentioned genes in Manipuri Muslims, an endogamous religious community constituting ~8% of the Manipur population.

Differences in conventional cardiovascular risk factors in two ethnic groups in India.

Background: Studies have been carried out at national and international levels to assess ethnic variations in the prevalence of cardiovascular diseases and their risk factors. However, ethnic variations in the contribution of various risk factors to complex diseases have been scarcely studied.

Objectives: Our study examined such variations in two ethnic groups in India, namely, Meiteis of Manipur (northeast India) and Aggarwals of Delhi (north India).