Recent advances and prospects in the Zn-catalysed Mannich reaction.

Zn-catalysed reactions are ubiquitously important due to their inexpensive, generally less toxic and atom-economic nature. According to the modern criteria of sustainability, their use in a catalytic manner is a highly desirable goal, especially when using chiral ligands. Considering the relevance of well-established zinc-mediated C-C bond formation reactions, it is relatively surprising that the use of Zn as a catalyst is still underdeveloped, especially in comparison with other transition metals.