Publications by authors named "Salaheddine Madhoun"
Article Synopsis
- The study aimed to explore how topical 2% ripasudil (a Rho kinase inhibitor) protects the nervous system, specifically looking at retinal ganglion cell (RGC) loss in mice exposed to increased intraocular pressure (IOP) and optic nerve damage.
- Results showed that ripasudil significantly reduced RGC axon and soma loss compared to saline-treated controls, indicating its protective effects against nerve damage.
- The findings suggest that ripasudil works by suppressing ROCK signaling pathways in the retina and optic nerve, affecting both RGCs and astrocyte responses to elevated IOP.
To identify changes in response to experimental intraocular pressure (IOP) elevation associated with the laminin α1 nmf223 mutation in mice. Laminin mutant (LM) mice (Lama1) and C57BL/6J (B6) mice in two age groups each (4-5 months and >1 year) underwent intracameral microbead injections to produce unilaterally elevated IOP. We assessed axonal transport block of immunofluorescently labeled amyloid precursor protein (APP) after 3 days and retinal ganglion cell (RGC) axon loss after 6 weeks.
View Article and Find Full Text PDFTraumatic brain injury (TBI), caused by repeated concussive head trauma can induce chronic traumatic encephalopathy (CTE), a neurodegenerative disease featuring behavioral symptoms ranging from cognitive deficits to elevated aggression. In a model, we used a high-impact trauma device (Katzenberger et al., 2013, 2015) to induce TBI-like symptoms and to study post-TBI behavioral outcomes.
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